Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

Dimitrios Farmakiotis; Fazal Shirazi; Yanan Zhao; Peguy J. Saad; Nathaniel D. Albert; Emmanuel Roilides; Thomas J. Walsh; David S. Perlin; Dimitrios P. Kontoyiannis

doi:10.1093/infdis/jiu289

Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

Dimitrios Farmakiotis, Fazal Shirazi, Yanan Zhao, Peguy J. Saad, Nathaniel D. Albert, Emmanuel Roilides, Thomas J. Walsh, David S. Perlin, Dimitrios P. Kontoyiannis

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.

Original language	English (US)
Pages (from-to)	1471-1475
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	210
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiu289
State	Published - Nov 1 2014

Keywords

Animal models
Apoptosis
Corticosteroids
Exserohilum rostratum
Virulence

ASJC Scopus subject areas

Medicine(all)

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10.1093/infdis/jiu289

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Farmakiotis, D., Shirazi, F., Zhao, Y., Saad, P. J., Albert, N. D., Roilides, E., Walsh, T. J., Perlin, D. S., & Kontoyiannis, D. P. (2014). Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies. Journal of Infectious Diseases, 210(9), 1471-1475. https://doi.org/10.1093/infdis/jiu289

Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies. / Farmakiotis, Dimitrios; Shirazi, Fazal; Zhao, Yanan et al.
In: Journal of Infectious Diseases, Vol. 210, No. 9, 01.11.2014, p. 1471-1475.

Research output: Contribution to journal › Article › peer-review

Farmakiotis, D, Shirazi, F, Zhao, Y, Saad, PJ, Albert, ND, Roilides, E, Walsh, TJ, Perlin, DS & Kontoyiannis, DP 2014, 'Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies', Journal of Infectious Diseases, vol. 210, no. 9, pp. 1471-1475. https://doi.org/10.1093/infdis/jiu289

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abstract = "High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.",

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AU - Roilides, Emmanuel

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Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

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