TY - JOUR
T1 - Methylprednisolone Ameliorates Retinal Photic Injury in Rats
AU - Rosner, Mordechai
AU - Lam, Tim T.
AU - Jun, J.
AU - Tso, Mark O.M.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1992/6
Y1 - 1992/6
N2 - Since lipid peroxidation induced by oxygen free radicals is believed to play an important role in retinal photic injury and high doses of certain steroids have been demonstrated to inhibit lipid peroxidation, we evaluated the effect of high-dose methylprednisolone sodium succinate on retinal injury inflicted by green light (490 to 580 nm, 160 to 180 foot-candles [1721.6 to 1936.8 lux]) for 24 hours in 36 rats. Animals received either intraperitoneal injections of the drug (80 mg/kg twice daily) or saline as a control, twice daily for 2 days, commencing with light exposure. The retinal photic injury was assessed 6 hours, 6 days, and 14 days after light exposure by light and electron microscopy, morphometric study of outer nuclear layer thickness and count of subretinal macrophages, and spectrophotometric measurement of rhodopsin. A beneficial effect of high-dose methylprednisolone was observed in retinal photic injury.
AB - Since lipid peroxidation induced by oxygen free radicals is believed to play an important role in retinal photic injury and high doses of certain steroids have been demonstrated to inhibit lipid peroxidation, we evaluated the effect of high-dose methylprednisolone sodium succinate on retinal injury inflicted by green light (490 to 580 nm, 160 to 180 foot-candles [1721.6 to 1936.8 lux]) for 24 hours in 36 rats. Animals received either intraperitoneal injections of the drug (80 mg/kg twice daily) or saline as a control, twice daily for 2 days, commencing with light exposure. The retinal photic injury was assessed 6 hours, 6 days, and 14 days after light exposure by light and electron microscopy, morphometric study of outer nuclear layer thickness and count of subretinal macrophages, and spectrophotometric measurement of rhodopsin. A beneficial effect of high-dose methylprednisolone was observed in retinal photic injury.
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U2 - 10.1001/archopht.1992.01080180129040
DO - 10.1001/archopht.1992.01080180129040
M3 - Article
C2 - 1596235
AN - SCOPUS:0026632431
SN - 0003-9950
VL - 110
SP - 857
EP - 861
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 6
ER -