Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: Synthesis from an epoxide and mechanisms

Youli Xiao; Rodney L. Nyland; Caren L.Freel Meyers; Pinghua Liu

doi:10.1039/c0cc02594a

Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: Synthesis from an epoxide and mechanisms

Youli Xiao, Rodney L. Nyland, Caren L.Freel Meyers, Pinghua Liu

School of Medicine

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

In this communication, we reported another unique IspG-catalyzed transformation, the production of its substrate, MEcPP, from (2R,3R)-4-hydroxy-3-methyl-2,3-epoxybutanyl diphosphate (Epoxy-HMBPP) when reductants are excluded from the reaction mixture.

Original language	English (US)
Pages (from-to)	7220-7222
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	38
DOIs	https://doi.org/10.1039/c0cc02594a
State	Published - Oct 14 2010

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Chemistry(all)
Catalysis

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abstract = "In this communication, we reported another unique IspG-catalyzed transformation, the production of its substrate, MEcPP, from (2R,3R)-4-hydroxy-3-methyl-2,3-epoxybutanyl diphosphate (Epoxy-HMBPP) when reductants are excluded from the reaction mixture.",

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AU - Meyers, Caren L.Freel

AU - Liu, Pinghua

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AB - In this communication, we reported another unique IspG-catalyzed transformation, the production of its substrate, MEcPP, from (2R,3R)-4-hydroxy-3-methyl-2,3-epoxybutanyl diphosphate (Epoxy-HMBPP) when reductants are excluded from the reaction mixture.

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Methylerythritol cyclodiphosphate (MEcPP) in deoxyxylulose phosphate pathway: Synthesis from an epoxide and mechanisms

Abstract

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