Methinks it is like a folding curve

Rajgopal Srinivasan, George D. Rose

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Most often, the unfolded state of peptides and proteins has been modeled as a statistical random coil. Here, we suggest an alternative model based on the presence of a significant, temperature-dependent conformational bias in the unfolded population. Conformational bias is suggested by our calculations [Proc. Natl. Acad. Sci. USA 96 (1999) 14258-14263], and it is found in recent studies of both proteins and peptides. The imposition of even a modest bias would transform our assessment of the folding problem.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalBiophysical Chemistry
StatePublished - Dec 10 2002


  • Conformational entropy
  • Protein folding
  • Random coil

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Organic Chemistry


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