Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages

Beth Kelly, Gillian M. Tannahill, Michael P. Murphy, Luke A.J. O'Neill

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The antidiabetic drug and mitochondrial NADH:ubiquinone oxidoreductase (complex I) inhibitor metformin has anti-inflammatory activity. Results: Complex I inhibition decreases LPS-induced IL-1β and boosts IL-10. Mitochondrial ROS may be a signal driving LPS-induced IL-1β. Conclusion: Complex I has a role in the induction of cytokines by LPS. Significance: This study provides insight into the anti-inflammatory action of metformin and reveals a role for complex I dysfunction in inflammatory signaling.

Original languageEnglish (US)
Pages (from-to)20348-20359
Number of pages12
JournalJournal of Biological Chemistry
Volume290
Issue number33
DOIs
StatePublished - Aug 14 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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