Metformin adjunctive therapy does not improve the sterilizing activity of the first-line antitubercular regimen in mice

Noton K. Dutta; Michael L. Pinn; Petros C. Karakousis

doi:10.1128/AAC.00652-17

Metformin adjunctive therapy does not improve the sterilizing activity of the first-line antitubercular regimen in mice

Noton K. Dutta, Michael L. Pinn, Petros C. Karakousis

School of Medicine

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given in combination with the first-line regimen against chronic tuberculosis in BALB/c mice. Mice receiving metformin adjunctive therapy had similar lung bacillary burdens with control mice during treatment, and the proportion of mice with microbiological relapse was similar between the two groups.

Original language	English (US)
Article number	e00652
Journal	Antimicrobial agents and chemotherapy
Volume	61
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00652-17
State	Published - Aug 2017

Keywords

BALB/c
Bactericidal
Cure
Denver regimen
Host-directed therapy
Metformin
Mycobacterium tuberculosis
Relapse
Standard first-line regimen
Sterilizing

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00652-17

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title = "Metformin adjunctive therapy does not improve the sterilizing activity of the first-line antitubercular regimen in mice",

abstract = "Preliminary preclinical and observational studies suggest the potential utility of metformin as an adjunctive, host-directed agent for treatment of tuberculosis (TB). In this study, we sought to investigate the bactericidal and sterilizing activities of human-like exposures of metformin when given in combination with the first-line regimen against chronic tuberculosis in BALB/c mice. Mice receiving metformin adjunctive therapy had similar lung bacillary burdens with control mice during treatment, and the proportion of mice with microbiological relapse was similar between the two groups.",

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note = "Funding Information: Research reported in this publication was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases under award UH2AI122309 (to P.C.K.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding source had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. We declare no conflicts of interest. Publisher Copyright: {\textcopyright} 2017 American Society for Microbiology. All Rights Reserved.",

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N1 - Funding Information: Research reported in this publication was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases under award UH2AI122309 (to P.C.K.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funding source had no role in the study design, data collection, data analysis, data interpretation, or writing of the report. We declare no conflicts of interest. Publisher Copyright: © 2017 American Society for Microbiology. All Rights Reserved.

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Metformin adjunctive therapy does not improve the sterilizing activity of the first-line antitubercular regimen in mice

Abstract

Keywords

ASJC Scopus subject areas

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