Abstract
Background: The mechanism underlying the activation of AMPK by metformin remains unclear. Results: Metformin promotes the formation of AMPK αβγ heterotrimeric complex. Conclusion: The formation of the AMPK αβγ heterotrimeric complex augments AMPK αβγ phosphorylation by LKB1 and prevents dephosphorylation by protein phosphatase. Significance: Metformin-mediated formation of the AMPK αβγ heterotrimeric complex results in AMPK activation by elevating AMPK phosphorylation at Thr-172.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3393-3802 |
| Number of pages | 410 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 6 |
| DOIs | |
| State | Published - Feb 6 2015 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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