Metastatic urothelial carcinoma to the liver with unknown primary tumor

Carling Cheung, Li Zhang, Marisa M. Clifton, Alyssa Park, Matthew Meissner, Brant R. Fulmer

Research output: Contribution to journalArticlepeer-review


Cancer of unknown primary (CUP), a rare and aggressive clinical entity, accounts for approximately 3% of all malignancies. CUP with urothelial origin is even more unusual, with no other cases reported in the current literature. As imaging and other studies often do not reveal the tumor origin, the approach to CUP involves a focused search for the primary tumor, relying on guidance from immunohistochemical staining of biopsy specimens. Treatment consists of standard therapies directed at the most likely tumor origin.

Original languageEnglish (US)
Article number100993
JournalUrology Case Reports
StatePublished - Nov 2019
Externally publishedYes


  • Cancer of unknown primary
  • Metastatic urothelial tumor

ASJC Scopus subject areas

  • Urology


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