Metastatic prostate cancer: Initial findings of PET with 2-deoxy-2-[F-18]fluoro-D-glucose

Paul D. Shreve, H. Barton Grossman, Milton D. Gross, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

327 Scopus citations


PURPOSE: To evaluate the accuracy of positron emission tomography (FET) with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) in the detection of osseous and soft-tissue metastases of prostate cancer. MATERIALS AND METHODS: Thirty-four patients (mean age, 71 years) with biopsy-proved prostate cancer and known or suspected metastatic disease were examined. Blinded interpretation of the PET images was compared with bone scan, CT, and clinical follow-up findings. RESULTS: In 202 untreated osseous metastases in 22 patients, the sensitivity of FDG PET was 65% (131 of 202 metastases), with a positive predictive value of 98% (131 of 133 positive findings). The estimated standardized uptake value in metastases was 2.1-5.7. Soft-tissue metastases to the lymph nodes or liver were identified, but evaluation of pelvic lymph node metastases was severely limited because of bladder tracer activity. CONCLUSION: FDG PET can help identify osseous and soft-tissue metastases of prostate cancer with a high positive predictive value but is less sensitive than bone scintigraphy in the identification of osseous metastases.

Original languageEnglish (US)
Pages (from-to)751-756
Number of pages6
Issue number3
StatePublished - Jun 1996


  • Bone neoplasms, radionuclide studies, 40.12163, 40.30
  • Bone neoplasms, secondary, 30.33, 40.33
  • Emission CT (ECT), comparative studies
  • Liver neoplasms, secondary, 761.12163, 761.33
  • Lymphatic system, neoplasms, 99.33
  • Prostate, neoplasms, 844.30

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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