Metastasis-Promoting Immunity: When T Cells Turn to the Dark Side

Drew Pardoll

doi:10.1016/j.ccr.2009.07.007

Metastasis-Promoting Immunity: When T Cells Turn to the Dark Side

Drew Pardoll

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.

Original language	English (US)
Pages (from-to)	81-82
Number of pages	2
Journal	Cancer cell
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.ccr.2009.07.007
State	Published - Aug 4 2009

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccr.2009.07.007

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title = "Metastasis-Promoting Immunity: When T Cells Turn to the Dark Side",

abstract = "While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.",

author = "Drew Pardoll",

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AU - Pardoll, Drew

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N2 - While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.

AB - While the role of endogenous T cells in antitumor immunity is being debated, little is known about whether and how T cells promote tumorigenesis. In this issue of Cancer Cell, DeNardo and colleagues demonstrate that IL-4-producing T cells enhance metastasis by programming macrophages to produce factors that enhance tumor invasion.

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JO - Cancer cell

JF - Cancer cell

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Metastasis-Promoting Immunity: When T Cells Turn to the Dark Side

Abstract

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