Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Andrew J. Ewald

doi:10.15252/embj.201899144

Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Andrew J. Ewald

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.

Original language	English (US)
Article number	e99144
Journal	EMBO Journal
Volume	37
Issue number	7
DOIs	https://doi.org/10.15252/embj.201899144
State	Published - Apr 3 2018

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

Access to Document

10.15252/embj.201899144

Cite this

@article{8aea15cafaec40dd8b3245f9f5c07931,

title = "Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity",

abstract = "Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.",

author = "Ewald, {Andrew J.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Author.",

year = "2018",

month = apr,

day = "3",

doi = "10.15252/embj.201899144",

language = "English (US)",

volume = "37",

journal = "EMBO Journal",

issn = "0261-4189",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Metastasis inside-out

T2 - Dissemination of cancer cell clusters with inverted polarity

AU - Ewald, Andrew J.

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.

AB - Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.

UR - http://www.scopus.com/inward/record.url?scp=85043385373&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043385373&partnerID=8YFLogxK

U2 - 10.15252/embj.201899144

DO - 10.15252/embj.201899144

M3 - Article

C2 - 29523585

AN - SCOPUS:85043385373

SN - 0261-4189

VL - 37

JO - EMBO Journal

JF - EMBO Journal

IS - 7

M1 - e99144

ER -

Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this