Metastasis inside-out: Dissemination of cancer cell clusters with inverted polarity

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3 Scopus citations


Zajac et al (2018) utilize patient tissue to discover a novel cellular mechanism for metastasis in colorectal cancer. They isolated cancer cell clusters from patient peritoneal fluid and demonstrated that these clusters invaded collectively into collagen gels, patient-derived tissues, and through the peritoneum of mice. During invasion the clusters retained an inverted epithelial architecture, functioning as multicellular metastatic seeds with inverted polarity.

Original languageEnglish (US)
Article numbere99144
JournalEMBO Journal
Issue number7
StatePublished - Apr 3 2018

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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