Metaplastic carcinoma of the breast with neuroglial differentiation

Mehra Golshan, Adam Kuten, Jacquleine William, Andrea Richardson, Amir Modarressi, Ursula Matulonis

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We present a case of a 34-year-old female who had a rapidly enlarging right breast mass. Biopsy results were consistent with a neuroblastic neoplasm of the breast. Neoadjuvant chemotherapy for a neuroblastoma was performed followed by a modified radical mastectomy was performed. Final pathology revealed small foci of poorly differentiated carcinoma randomly distributed within extensive areas of neuroglial differentiation. Such a lesion has not been described in the current literature to our knowledge, and we propose that this neoplasm is a metaplastic carcinoma with a novel heterogeneous differentiation. Subsequent therapy consisted of standard adjuvant breast cancer chemotherapy and radiation therapy.

Original languageEnglish (US)
Pages (from-to)545-549
Number of pages5
Issue number4
StatePublished - Aug 2006
Externally publishedYes


  • Metaplastic carcinoma
  • Neoadjuvant chemotherapy
  • Neuroglial differentiation

ASJC Scopus subject areas

  • Surgery
  • Oncology
  • Cancer Research


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