TY - JOUR
T1 - Metabolomic Profiles Associated with Blood Pressure Reduction in Response to the DASH and DASH-Sodium Dietary Interventions
AU - Kim, Hyunju
AU - Appel, Lawrence J.
AU - Lichtenstein, Alice H.
AU - Wong, Kari E.
AU - Chatterjee, Nilanjan
AU - Rhee, Eugene P.
AU - Rebholz, Casey M.
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/7
Y1 - 2023/7
N2 - Background: The DASH (Dietary Approaches to Stop Hypertension) diets reduced blood pressure (BP) in the DASH and DASH-Sodium trials, but the underlying mechanisms are unclear. We identified metabolites associated with systolic BP or diastolic BP (DBP) changes induced by dietary interventions (DASH versus control arms) in 2 randomized controlled feeding studies - the DASH and DASH-Sodium trials. Methods: Metabolomic profiling was conducted in serum and urine samples collected at the end of diet interventions: DASH (n=219) and DASH-Sodium (n=395). Using multivariable linear regression models, associations were examined between metabolites and change in systolic BP and DBP. Tested for interactions between diet interventions and metabolites were the following comparisons: (1) DASH versus control diets in the DASH trial (serum), (2) DASH high-sodium versus control high-sodium diets in the DASH-Sodium trial (urine), and (3) DASH low-sodium versus control high-sodium diets in the DASH-Sodium trial (urine). Results: Sixty-five significant interactions were identified (DASH trial [serum], 12; DASH high sodium [urine], 35; DASH low sodium [urine], 18) between metabolites and systolic BP or DBP. In the DASH trial, serum tryptophan betaine was associated with reductions in DBP in participants consuming the DASH diets but not control diets (P interaction, 0.023). In the DASH-Sodium trial, urine levels of N-methylglutamate and proline derivatives (eg, stachydrine, 3-hydroxystachydrine, N-methylproline, and N-methylhydroxyproline) were associated with reductions in systolic BP or DBP in participants consuming the DASH diets but not control diets (P interaction, <0.05 for all tests). Conclusions: We identified metabolites that were associated with BP lowering in response to dietary interventions. Registration: URL: https://www.clinicaltrials.gov/ct2/show/NCT03403166; Unique identifier: NCT03403166 (DASH trial). URL: https://www.clinicaltrials.gov/ct2/show/NCT00000608; Unique identifier: NCT00000608 (DASH-Sodium trial).
AB - Background: The DASH (Dietary Approaches to Stop Hypertension) diets reduced blood pressure (BP) in the DASH and DASH-Sodium trials, but the underlying mechanisms are unclear. We identified metabolites associated with systolic BP or diastolic BP (DBP) changes induced by dietary interventions (DASH versus control arms) in 2 randomized controlled feeding studies - the DASH and DASH-Sodium trials. Methods: Metabolomic profiling was conducted in serum and urine samples collected at the end of diet interventions: DASH (n=219) and DASH-Sodium (n=395). Using multivariable linear regression models, associations were examined between metabolites and change in systolic BP and DBP. Tested for interactions between diet interventions and metabolites were the following comparisons: (1) DASH versus control diets in the DASH trial (serum), (2) DASH high-sodium versus control high-sodium diets in the DASH-Sodium trial (urine), and (3) DASH low-sodium versus control high-sodium diets in the DASH-Sodium trial (urine). Results: Sixty-five significant interactions were identified (DASH trial [serum], 12; DASH high sodium [urine], 35; DASH low sodium [urine], 18) between metabolites and systolic BP or DBP. In the DASH trial, serum tryptophan betaine was associated with reductions in DBP in participants consuming the DASH diets but not control diets (P interaction, 0.023). In the DASH-Sodium trial, urine levels of N-methylglutamate and proline derivatives (eg, stachydrine, 3-hydroxystachydrine, N-methylproline, and N-methylhydroxyproline) were associated with reductions in systolic BP or DBP in participants consuming the DASH diets but not control diets (P interaction, <0.05 for all tests). Conclusions: We identified metabolites that were associated with BP lowering in response to dietary interventions. Registration: URL: https://www.clinicaltrials.gov/ct2/show/NCT03403166; Unique identifier: NCT03403166 (DASH trial). URL: https://www.clinicaltrials.gov/ct2/show/NCT00000608; Unique identifier: NCT00000608 (DASH-Sodium trial).
KW - blood pressure
KW - dietary approaches to stop hypertension
KW - hypertension
KW - metabolic networks and pathways
KW - metabolomics
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UR - http://www.scopus.com/inward/citedby.url?scp=85163178302&partnerID=8YFLogxK
U2 - 10.1161/HYPERTENSIONAHA.123.20901
DO - 10.1161/HYPERTENSIONAHA.123.20901
M3 - Article
C2 - 37161796
AN - SCOPUS:85163178302
SN - 0194-911X
VL - 80
SP - 1494
EP - 1506
JO - Hypertension
JF - Hypertension
IS - 7
ER -