Metabolites in ventrilcular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging

Lidia M. Nagae-Poetscher; Michael McMahon; Nancy Braverman; William T. Lawrie; Ali Fatemi; Mahaveer Degaonkar; Alena Horská; Martin G. Pomper; Vaddapuram P. Chacko; Peter B. Barker

doi:10.1002/jmri.20128

Metabolites in ventrilcular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging

Lidia M. Nagae-Poetscher, Michael McMahon, Nancy Braverman, William T. Lawrie, Ali Fatemi, Mahaveer Degaonkar, Alena Horská, Martin G. Pomper, Vaddapuram P. Chacko, Peter B. Barker

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.

Original language	English (US)
Pages (from-to)	496-500
Number of pages	5
Journal	Journal of Magnetic Resonance Imaging
Volume	20
Issue number	3
DOIs	https://doi.org/10.1002/jmri.20128
State	Published - 2004

Keywords

Acetone
Brain
CSF
Lactate
Propan-1,2-diol
Spectroscopy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/jmri.20128

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title = "Metabolites in ventrilcular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging",

abstract = "Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.",

keywords = "Acetone, Brain, CSF, Lactate, Propan-1,2-diol, Spectroscopy",

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T1 - Metabolites in ventrilcular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging

AU - Nagae-Poetscher, Lidia M.

AU - McMahon, Michael

AU - Braverman, Nancy

AU - Lawrie, William T.

AU - Fatemi, Ali

AU - Degaonkar, Mahaveer

AU - Horská, Alena

AU - Pomper, Martin G.

AU - Chacko, Vaddapuram P.

AU - Barker, Peter B.

PY - 2004

Y1 - 2004

N2 - Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.

AB - Normally, ventricular cerebrospinal fluid (CSF) contains low levels of all metabolite signals on proton magnetic resonance spectroscopic imaging (MRSI). We present here three cases (two with seizure disorders, one with a central nervous system lymphoma) who presented with unusually elevated CSF signals on MRSI. Based on chemical shifts and in vitro studies (in one case), the signals were assigned to propan-1,2-diol (PD), acetone, and lactate, respectively. These compounds were either exclusively, or more readily, detected in CSF than in brain. Proton MRSI conveniently screens both brain and CSF for abnormal metabolism simultaneously.

KW - Acetone

KW - Brain

KW - CSF

KW - Lactate

KW - Propan-1,2-diol

KW - Spectroscopy

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JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

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ER -

Metabolites in ventrilcular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging

Abstract

Keywords

ASJC Scopus subject areas

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