Metabolism in type 2 immune responses

Agnieszka M. Kabat; Erika L. Pearce; Edward J. Pearce

doi:10.1016/j.immuni.2023.03.007

Metabolism in type 2 immune responses

Agnieszka M. Kabat, Erika L. Pearce, Edward J. Pearce

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The immune response is tailored to the environment in which it takes place. Immune cells sense and adapt to changes in their surroundings, and it is now appreciated that in addition to cytokines made by stromal and epithelial cells, metabolic cues provide key adaptation signals. Changes in immune cell activation states are linked to changes in cellular metabolism that support function. Furthermore, metabolites themselves can signal between as well as within cells. Here, we discuss recent progress in our understanding of how metabolic regulation relates to type 2 immunity firstly by considering specifics of metabolism within type 2 immune cells and secondly by stressing how type 2 immune cells are integrated more broadly into the metabolism of the organism as a whole.

Original language	English (US)
Pages (from-to)	723-741
Number of pages	19
Journal	Immunity
Volume	56
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2023.03.007
State	Published - Apr 11 2023

ASJC Scopus subject areas

Infectious Diseases
Immunology and Allergy
Immunology

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10.1016/j.immuni.2023.03.007

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title = "Metabolism in type 2 immune responses",

abstract = "The immune response is tailored to the environment in which it takes place. Immune cells sense and adapt to changes in their surroundings, and it is now appreciated that in addition to cytokines made by stromal and epithelial cells, metabolic cues provide key adaptation signals. Changes in immune cell activation states are linked to changes in cellular metabolism that support function. Furthermore, metabolites themselves can signal between as well as within cells. Here, we discuss recent progress in our understanding of how metabolic regulation relates to type 2 immunity firstly by considering specifics of metabolism within type 2 immune cells and secondly by stressing how type 2 immune cells are integrated more broadly into the metabolism of the organism as a whole.",

author = "Kabat, {Agnieszka M.} and Pearce, {Erika L.} and Pearce, {Edward J.}",

note = "Funding Information: We thank members of the E.J.P. and E.L.P. laboratories, and especially Drs. Anna Kania, Katarzyna Grzes, and David Sanin for helpful discussions. E.J.P. and E.L.P. are supported by Bloomberg Distinguished Professorships. E.L.P. is supported by National Institutes of Health R01AI156274 . Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

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AU - Pearce, Erika L.

AU - Pearce, Edward J.

N1 - Funding Information: We thank members of the E.J.P. and E.L.P. laboratories, and especially Drs. Anna Kania, Katarzyna Grzes, and David Sanin for helpful discussions. E.J.P. and E.L.P. are supported by Bloomberg Distinguished Professorships. E.L.P. is supported by National Institutes of Health R01AI156274 . Publisher Copyright: © 2023 Elsevier Inc.

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N2 - The immune response is tailored to the environment in which it takes place. Immune cells sense and adapt to changes in their surroundings, and it is now appreciated that in addition to cytokines made by stromal and epithelial cells, metabolic cues provide key adaptation signals. Changes in immune cell activation states are linked to changes in cellular metabolism that support function. Furthermore, metabolites themselves can signal between as well as within cells. Here, we discuss recent progress in our understanding of how metabolic regulation relates to type 2 immunity firstly by considering specifics of metabolism within type 2 immune cells and secondly by stressing how type 2 immune cells are integrated more broadly into the metabolism of the organism as a whole.

AB - The immune response is tailored to the environment in which it takes place. Immune cells sense and adapt to changes in their surroundings, and it is now appreciated that in addition to cytokines made by stromal and epithelial cells, metabolic cues provide key adaptation signals. Changes in immune cell activation states are linked to changes in cellular metabolism that support function. Furthermore, metabolites themselves can signal between as well as within cells. Here, we discuss recent progress in our understanding of how metabolic regulation relates to type 2 immunity firstly by considering specifics of metabolism within type 2 immune cells and secondly by stressing how type 2 immune cells are integrated more broadly into the metabolism of the organism as a whole.

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Metabolism in type 2 immune responses

Abstract

ASJC Scopus subject areas

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