Metabolic oligosaccharide engineering with N-Acyl functionalized ManNAc analogs: Cytotoxicity, metabolic flux, and glycan-display considerations

Engineering & Materials Science

• Monosaccharides 100%
• Oligosaccharides 99%
• Cytotoxicity 86%
• Fluxes 47%
• Display devices 44%
• Cells 37%
• Cell death 28%
• Ketones 27%
• Functional groups 25%
• Biotechnology 24%
• Fatty acids 23%
• Sugars 23%
• Reagents 23%
• Animals 18%

Medicine & Life Sciences

• Metabolic Engineering 79%
• Oligosaccharides 64%
• Polysaccharides 54%
• peracetylated N-azidoacetylmannosamine 51%
• Azides 49%
• Monosaccharides 45%
• Click Chemistry 18%
• Glycocalyx 15%
• Technology 15%
• Ketones 14%
• Volatile Fatty Acids 14%
• Structure-Activity Relationship 13%
• Biotechnology 13%
• Hydroxyl Radical 12%
• Sugars 11%
• Ligation 10%
• Apoptosis 7%
• Animals 5%
• Pharmaceutical Preparations 4%
• Neoplasms 3%

Chemical Compounds

• Monosaccharide 61%
• Oligosaccharide 54%
• Metabolic 47%
• Azide 35%
• Short-Chain Fatty Acid 27%
• Apoptotic 22%
• Biotechnology 20%
• Mammalian Cell 20%
• Antineoplastic Agent 17%
• Structure-Activity Relationship 16%
• Surface 12%