TY - JOUR
T1 - Metabolic imaging of myocardial triglyceride content
T2 - Reproducibility of 1H MR spectroscopy with respiratory navigator gating in volunteers
AU - Van Der Meer, Rutger W.
AU - Doornbos, Joost
AU - Kozerke, Sebastian
AU - Schär, Michael
AU - Bax, Jeroen J.
AU - Hammer, Sebastiaan
AU - Smit, Johannes W.A.
AU - Romijn, Johannes A.
AU - Diamant, Michaela
AU - Rijzewijk, Luuk J.
AU - De Roos, Albert
AU - Lamb, Hildo J.
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age ± standard error, 31 years ± 2.8 [range, 19-60 years]; body mass index, 19-30 kg/m2) without history of cardiovascular disease, 1H MR spectroscopy of the myocardium was performed at rest, with and without respiratory motion compensation. Unsuppressed water signal linewidth changed from 11.9 Hz to 10.7 Hz (P < .001) with the use of the navigator, which indicated better spectral resolution. The navigator improved the intraclass correlation coefficient for the assessment of myocardial triglyceride content from 0.32 to 0.81. Therefore, the authors believe that respiratory motion correction is essential for reproducible assessment of myocardial triglycerides.
AB - Institutional review board approval and informed consent were obtained. The purpose of the study was to prospectively compare spectral resolution and reproducibility of hydrogen 1 (1H) magnetic resonance (MR) spectroscopy, with and without respiratory motion compensation based on navigator echoes, in the assessment of myocardial triglyceride content in the human heart. In 20 volunteers (14 men, six women; mean age ± standard error, 31 years ± 2.8 [range, 19-60 years]; body mass index, 19-30 kg/m2) without history of cardiovascular disease, 1H MR spectroscopy of the myocardium was performed at rest, with and without respiratory motion compensation. Unsuppressed water signal linewidth changed from 11.9 Hz to 10.7 Hz (P < .001) with the use of the navigator, which indicated better spectral resolution. The navigator improved the intraclass correlation coefficient for the assessment of myocardial triglyceride content from 0.32 to 0.81. Therefore, the authors believe that respiratory motion correction is essential for reproducible assessment of myocardial triglycerides.
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U2 - 10.1148/radiol.2451061904
DO - 10.1148/radiol.2451061904
M3 - Article
C2 - 17885193
AN - SCOPUS:34548677080
SN - 0033-8419
VL - 245
SP - 251
EP - 257
JO - RADIOLOGY
JF - RADIOLOGY
IS - 1
ER -