Metabolic conversion of methotrexate in man.

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6 Scopus citations


Metabolism of methotrexate (MTX) to closely related analogues has been increasingly recognized in recent years. 7-Hydroxymethotrexate, 2,4-diamino-N10-methylpteroic acid, and methotrexate poly-gamma-glutamates have been established as products of metabolic conversion in man. The significance of the formation of these metabolites has not been firmly established. Certain of these compounds may play a role in the development of the renal failure syndrome associated with high-dose infusions, contribute to the chronic toxicity of MTX administration, and cross-react to a significant degree in radioimmunoassay methods for measurement of MTX concentrations.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
StatePublished - Dec 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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