Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Debangshu Samanta; Gregg L Semenza

doi:10.1016/j.bbcan.2018.07.002

Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Debangshu Samanta, Gregg L Semenza

School of Medicine

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Cancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Hypoxia or low oxygen abundance is a common feature of the tumor microenvironment that occurs due to an imbalance in supply and demand. Many of the metabolic responses to hypoxia in both cancer cells and stromal cells are orchestrated by hypoxia-inducible factors (HIFs). In this review we summarize our current understanding of how HIFs modulate the metabolism of hypoxic cancer cells and immune cells, and how altered metabolism plays a role in cancer progression.

Original language	English (US)
Journal	Biochimica et Biophysica Acta - Reviews on Cancer
DOIs	https://doi.org/10.1016/j.bbcan.2018.07.002
State	Accepted/In press - Jan 1 2018

ASJC Scopus subject areas

Oncology
Genetics
Cancer Research

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10.1016/j.bbcan.2018.07.002

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abstract = "Cancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Hypoxia or low oxygen abundance is a common feature of the tumor microenvironment that occurs due to an imbalance in supply and demand. Many of the metabolic responses to hypoxia in both cancer cells and stromal cells are orchestrated by hypoxia-inducible factors (HIFs). In this review we summarize our current understanding of how HIFs modulate the metabolism of hypoxic cancer cells and immune cells, and how altered metabolism plays a role in cancer progression.",

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AB - Cancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Hypoxia or low oxygen abundance is a common feature of the tumor microenvironment that occurs due to an imbalance in supply and demand. Many of the metabolic responses to hypoxia in both cancer cells and stromal cells are orchestrated by hypoxia-inducible factors (HIFs). In this review we summarize our current understanding of how HIFs modulate the metabolism of hypoxic cancer cells and immune cells, and how altered metabolism plays a role in cancer progression.

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Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Abstract

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