Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility

Ming Li, Yi Wang, Xue Bin Zheng, Masashi Ikeda, Nakao Iwata, Xiong Jian Luo, Siow Ann Chong, Jimmy Lee, Marcella Rietschel, Fengyu Zhang, Bertram Müller-Myhsok, Sven Cichon, Daniel R. Weinberger, Manuel Mattheisen, Thomas G. Schulze, Nicholas G. Martin, Philip B. Mitchell, Peter R. Schofield, Jian Jun Liu, Bing Su

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Recent genome-wide association studies have reported a set of schizophrenia susceptibility genes, but many of them await further replications in additional samples. Here we analyzed 5 genome-wide supported variants in a Han Chinese sample, and the variant rs2312147 at VRK2 showed significant association, which was confirmed in the meta-analysis combining multiple Asian and European samples (P=3.17×10-4, N=7498). Rs2312147 is also associated with brain structure in healthy subjects, including the total brain volume and the white matter volume. Gene expression analyses indicated an up-regulation of VRK2 in schizophrenia patients. Our data provide further evidence for the contribution of VRK2 to schizophrenia.

Original languageEnglish (US)
Pages (from-to)200-205
Number of pages6
JournalSchizophrenia Research
Issue number1-3
StatePublished - Dec 2012
Externally publishedYes


  • Asian populations
  • Brain imaging analysis
  • MRI
  • Schizophrenia
  • VRK2

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility'. Together they form a unique fingerprint.

Cite this