Abstract
Over the past decade, amniotic fluid-derived mesenchymal stem/stromal cells (AF-MSCs) have emerged as a novel, experimental approach for the treatment of a wide variety of congenital anomalies diagnosed either in utero or postnatally. This article gives a pediatric surgeon’s perspective on AF-MSC therapy for the management of congenital anomalies and other diseases. The current status in preterm AF-MSC research, particularly as it relates to tissue engineering-based applications, is described in various experimental animal models. A roadmap for further study and eventual clinical application is also proposed.
Original language | English (US) |
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Title of host publication | Encyclopedia of Tissue Engineering and Regenerative Medicine |
Publisher | Elsevier |
Pages | 513-520 |
Number of pages | 8 |
Volume | 1-3 |
ISBN (Electronic) | 9780128136997 |
ISBN (Print) | 9780128137000 |
DOIs | |
State | Published - Jan 1 2019 |
Externally published | Yes |
Keywords
- Amniocytes
- Amniotic fluid
- Congenital anomalies
- Fetal therapy
- Fetus
- Induced pluripotent stem cells
- Mesenchymal stem cells
- Stem cell therapy
- Stem cells
- Tissue engineering
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)