Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Julie M. Johnson-Nauroth; Jerome Graber; Karen Yao; Steve Jacobson; Peter A. Calabresi

doi:10.1016/j.jneuroim.2006.03.013

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Julie M. Johnson-Nauroth, Jerome Graber, Karen Yao, Steve Jacobson, Peter A. Calabresi

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA^-/CCR7^- T_EM and CD45RA⁺/CCR7^- T_Diff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Rα, failed to respond to IL-7 and IL-15, and did not develop a T_CM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of T_EM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.

Original language	English (US)
Pages (from-to)	115-124
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	176
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.03.013
State	Published - Jul 2006

Keywords

Cytotoxic T cells
Memory
Viral infection

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2006.03.013

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title = "Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells",

abstract = "Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA-/CCR7- TEM and CD45RA+/CCR7- TDiff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Rα, failed to respond to IL-7 and IL-15, and did not develop a TCM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of TEM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.",

keywords = "Cytotoxic T cells, Memory, Viral infection",

author = "Johnson-Nauroth, {Julie M.} and Jerome Graber and Karen Yao and Steve Jacobson and Calabresi, {Peter A.}",

note = "Funding Information: This work was supported by NS041435 (PAC) and NINDS, NIH intramural program (SJ).",

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doi = "10.1016/j.jneuroim.2006.03.013",

language = "English (US)",

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AU - Johnson-Nauroth, Julie M.

AU - Graber, Jerome

AU - Yao, Karen

AU - Jacobson, Steve

AU - Calabresi, Peter A.

N1 - Funding Information: This work was supported by NS041435 (PAC) and NINDS, NIH intramural program (SJ).

PY - 2006/7

Y1 - 2006/7

N2 - Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA-/CCR7- TEM and CD45RA+/CCR7- TDiff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Rα, failed to respond to IL-7 and IL-15, and did not develop a TCM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of TEM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.

AB - Cytotoxic memory T cells play a critical role in combating viral infections; however, in some diseases they may contribute to tissue damage. In HAM/TSP, HTLV-1 Tax 11-19+ cells proliferate spontaneously in vitro and can be tracked using the Tax 11-19 MHC Class I tetramer. Immediately ex vivo, these cells were a mix of CD45RA-/CCR7- TEM and CD45RA+/CCR7- TDiff memory CTL. The subsequent proliferating Tax 11-19 tetramer+ population expressed low levels of IL-7Rα, failed to respond to IL-7 and IL-15, and did not develop a TCM phenotype. Thus, chronic exposure to viral antigen may result in a sustained pool of TEM cells that home to the CNS and mediate the spinal cord pathology seen in this disease.

KW - Cytotoxic T cells

KW - Memory

KW - Viral infection

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ER -

Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells

Abstract

Keywords

ASJC Scopus subject areas

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