Membranes are not just rafts

Saame Raza Shaikh, Michael A. Edidin

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


A new definition for lipid rafts was coined at the Keystone Symposium of Lipid Rafts and Cell Function based on recent advances in the field. The revised definition lumps all membrane heterogeneities that are not rafts into a single class of "non-raft". In this commentary, we suggest that "non-raft" domains encompass a variety of membrane heterogeneities and are quite diverse in composition and origin. A good starting point for the study of this diversity would be phospholipids with unsaturated acyl chains, which display little affinity for cholesterol; these lipids are abundant in membranes such as the endoplasmic reticulum and that may form their own macro- or microdomains.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalChemistry and Physics of Lipids
Issue number1
StatePublished - Oct 2006


  • Lipid raft
  • Membranes
  • Non-raft

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology


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