Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

Zoe Cournia; Toby W. Allen; Ioan Andricioaei; Bruno Antonny; Daniel Baum; Grace Brannigan; Nicolae Viorel Buchete; Jason T. Deckman; Lucie Delemotte; Coral del Val; Ran Friedman; Paraskevi Gkeka; Hans Christian Hege; Jérôme Hénin; Marina A. Kasimova; Antonios Kolocouris; Michael L. Klein; Syma Khalid; M. Joanne Lemieux; Norbert Lindow; Mahua Roy; Jana Selent; Mounir Tarek; Florentina Tofoleanu; Stefano Vanni; Sinisa Urban; David J. Wales; Jeremy C. Smith; Ana Nicoleta Bondar

doi:10.1007/s00232-015-9802-0

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

Zoe Cournia, Toby W. Allen, Ioan Andricioaei, Bruno Antonny, Daniel Baum, Grace Brannigan, Nicolae Viorel Buchete, Jason T. Deckman, Lucie Delemotte, Coral del Val, Ran Friedman, Paraskevi Gkeka, Hans Christian Hege, Jérôme Hénin, Marina A. Kasimova, Antonios Kolocouris, Michael L. Klein, Syma Khalid, M. Joanne Lemieux, Norbert LindowMahua Roy, Jana Selent, Mounir Tarek, Florentina Tofoleanu, Stefano Vanni, Sinisa Urban, David J. Wales, Jeremy C. Smith, Ana Nicoleta Bondar

School of Medicine

Research output: Contribution to journal › Review article › peer-review

75 Scopus citations

Abstract

Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

Original language	English (US)
Pages (from-to)	611-640
Number of pages	30
Journal	Journal of Membrane Biology
Volume	248
Issue number	4
DOIs	https://doi.org/10.1007/s00232-015-9802-0
State	Published - Aug 27 2015

Keywords

Lipids
Membrane proteins
Membrane-mediated interactions
Protein dynamics
Protein function
Protein structure

ASJC Scopus subject areas

Biophysics
Physiology
Cell Biology

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10.1007/s00232-015-9802-0

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Cournia, Z., Allen, T. W., Andricioaei, I., Antonny, B., Baum, D., Brannigan, G., Buchete, N. V., Deckman, J. T., Delemotte, L., del Val, C., Friedman, R., Gkeka, P., Hege, H. C., Hénin, J., Kasimova, M. A., Kolocouris, A., Klein, M. L., Khalid, S., Lemieux, M. J., ... Bondar, A. N. (2015). Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory. Journal of Membrane Biology, 248(4), 611-640. https://doi.org/10.1007/s00232-015-9802-0

Cournia, Z, Allen, TW, Andricioaei, I, Antonny, B, Baum, D, Brannigan, G, Buchete, NV, Deckman, JT, Delemotte, L, del Val, C, Friedman, R, Gkeka, P, Hege, HC, Hénin, J, Kasimova, MA, Kolocouris, A, Klein, ML, Khalid, S, Lemieux, MJ, Lindow, N, Roy, M, Selent, J, Tarek, M, Tofoleanu, F, Vanni, S, Urban, S, Wales, DJ, Smith, JC & Bondar, AN 2015, 'Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory', Journal of Membrane Biology, vol. 248, no. 4, pp. 611-640. https://doi.org/10.1007/s00232-015-9802-0

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abstract = "Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.",

keywords = "Lipids, Membrane proteins, Membrane-mediated interactions, Protein dynamics, Protein function, Protein structure",

author = "Zoe Cournia and Allen, {Toby W.} and Ioan Andricioaei and Bruno Antonny and Daniel Baum and Grace Brannigan and Buchete, {Nicolae Viorel} and Deckman, {Jason T.} and Lucie Delemotte and {del Val}, Coral and Ran Friedman and Paraskevi Gkeka and Hege, {Hans Christian} and J{\'e}r{\^o}me H{\'e}nin and Kasimova, {Marina A.} and Antonios Kolocouris and Klein, {Michael L.} and Syma Khalid and Lemieux, {M. Joanne} and Norbert Lindow and Mahua Roy and Jana Selent and Mounir Tarek and Florentina Tofoleanu and Stefano Vanni and Sinisa Urban and Wales, {David J.} and Smith, {Jeremy C.} and Bondar, {Ana Nicoleta}",

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AU - Cournia, Zoe

AU - Allen, Toby W.

AU - Andricioaei, Ioan

AU - Antonny, Bruno

AU - Baum, Daniel

AU - Brannigan, Grace

AU - Buchete, Nicolae Viorel

AU - Deckman, Jason T.

AU - Delemotte, Lucie

AU - del Val, Coral

AU - Friedman, Ran

AU - Gkeka, Paraskevi

AU - Hege, Hans Christian

AU - Hénin, Jérôme

AU - Kasimova, Marina A.

AU - Kolocouris, Antonios

AU - Klein, Michael L.

AU - Khalid, Syma

AU - Lemieux, M. Joanne

AU - Lindow, Norbert

AU - Roy, Mahua

AU - Selent, Jana

AU - Tarek, Mounir

AU - Tofoleanu, Florentina

AU - Vanni, Stefano

AU - Urban, Sinisa

AU - Wales, David J.

AU - Smith, Jeremy C.

AU - Bondar, Ana Nicoleta

PY - 2015/8/27

Y1 - 2015/8/27

N2 - Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

AB - Membrane proteins mediate processes that are fundamental for the flourishing of biological cells. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. We present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

KW - Lipids

KW - Membrane proteins

KW - Membrane-mediated interactions

KW - Protein dynamics

KW - Protein function

KW - Protein structure

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JO - Journal of Membrane Biology

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Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

Abstract

Keywords

ASJC Scopus subject areas

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