Mediation of separation distress by α2-adrenergic mechanisms in a non-human primate

James C. Harris, John D. Newman

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


This study provides the first behavioral evidence in support of an α-adrenergic mechanism underlying imipramine's amelioration of separation distress. The rate of separation-induced vocalization by adult squirrel monkeys was decreased by imipramine and the α2-adrenergic agonist clonidine, and increased by the α2-adrenergic antagonist yohimbine. Yohimbine, but not the α1-antagonist prazosin, reversed the clonidine effect suggesting that drugs acting directly on α2-receptors may have a role in management of separation anxiety.

Original languageEnglish (US)
Pages (from-to)353-356
Number of pages4
JournalBrain research
Issue number2
StatePublished - May 5 1987
Externally publishedYes


  • Clonidine
  • Isolation call
  • Separation anxiety
  • Separation distress
  • Squirrel monkey
  • Yohimbine
  • α-Adrenergic receptor

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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