Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface

Sanghoon Lee; Hao Wang; Wendy Yen Xian Peh; Tianyiyi He; Shih Cheng Yen; Nitish V. Thakor; Chengkuo Lee

doi:10.1016/j.nanoen.2019.03.082

Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface

Sanghoon Lee, Hao Wang, Wendy Yen Xian Peh, Tianyiyi He, Shih Cheng Yen, Nitish V. Thakor, Chengkuo Lee

School of Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface. The detailed stimulation parameters such as current, pulse width, and charges generated by the proposed TENG were investigated for the stimulation of autonomic pelvic nerve. In in vivo experiments, different beats per minute (BPM) were delivered to the nerves to investigate the effect of stimulation frequency on mechano-neurostimulation while monitoring changes in bladder pressure and the occurrence of micturition. Furthermore, different numbers of pulses were applied to stimulate the pelvic nerve. The bladder contractions with micturition were observed when applying more than 50 BPM as well as one pulse. Comparison of stimulation was performed using a commercial stimulator with the similar long-pulse widths as generated by TENGs. In addition, chronic implantation of flexible clip interface was demonstrated with functionality test of the interface. The results demonstrate that this technology may potentially be used for self-powered mechano-neuromodulation for bladder function in the future.

Original language	English (US)
Pages (from-to)	449-456
Number of pages	8
Journal	Nano Energy
Volume	60
DOIs	https://doi.org/10.1016/j.nanoen.2019.03.082
State	Published - Jun 2019

Keywords

Mechano-neuromodulation
Neural clip interface
Pelvic nerve
Triboelectric nanogenerator
Underactive bladder

ASJC Scopus subject areas

Renewable Energy, Sustainability and the Environment
Materials Science(all)
Electrical and Electronic Engineering

Access to Document

10.1016/j.nanoen.2019.03.082

Cite this

@article{91e3058c6cbe4565b2b9e4ff5ede9873,

title = "Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface",

abstract = "Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface. The detailed stimulation parameters such as current, pulse width, and charges generated by the proposed TENG were investigated for the stimulation of autonomic pelvic nerve. In in vivo experiments, different beats per minute (BPM) were delivered to the nerves to investigate the effect of stimulation frequency on mechano-neurostimulation while monitoring changes in bladder pressure and the occurrence of micturition. Furthermore, different numbers of pulses were applied to stimulate the pelvic nerve. The bladder contractions with micturition were observed when applying more than 50 BPM as well as one pulse. Comparison of stimulation was performed using a commercial stimulator with the similar long-pulse widths as generated by TENGs. In addition, chronic implantation of flexible clip interface was demonstrated with functionality test of the interface. The results demonstrate that this technology may potentially be used for self-powered mechano-neuromodulation for bladder function in the future.",

keywords = "Mechano-neuromodulation, Neural clip interface, Pelvic nerve, Triboelectric nanogenerator, Underactive bladder",

author = "Sanghoon Lee and Hao Wang and {Xian Peh}, {Wendy Yen} and Tianyiyi He and Yen, {Shih Cheng} and Thakor, {Nitish V.} and Chengkuo Lee",

note = "Funding Information: This work was supported by grants from the National Research Foundation (NRF) CRP project {\textquoteleft}Peripheral Nerve Prostheses: A Paradigm Shift in Restoring Dexterous Limb Function{\textquoteright} (R-719-000-001-281), and HIFES Seed Funding-2017-01 grant (R-263-501-012-133) “Hybrid Integration of Flexible Power Source and Pressure Sensors” at the National University of Singapore; The DGIST Start-up Fund Program of the Ministry of Science and ICT (2019010072), the National Research Foundation of Korea (2019R1C1C1008344). Funding Information: This work was supported by grants from the National Research Foundation (NRF) CRP project {\textquoteleft}Peripheral Nerve Prostheses: A Paradigm Shift in Restoring Dexterous Limb Function{\textquoteright} ( R-719-000-001-281 ), and HIFES Seed Funding-2017-01 grant ( R-263-501-012-133 ) “ Hybrid Integration of Flexible Power Source and Pressure Sensors ” at the National University of Singapore; The DGIST Start-up Fund Program of the Ministry of Science and ICT ( 2019010072 ), the National Research Foundation of Korea ( 2019R1C1C1008344 ). Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = jun,

doi = "10.1016/j.nanoen.2019.03.082",

language = "English (US)",

volume = "60",

pages = "449--456",

journal = "Nano Energy",

issn = "2211-2855",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder

T2 - A triboelectric neurostimulator integrated with flexible neural clip interface

AU - Lee, Sanghoon

AU - Wang, Hao

AU - Xian Peh, Wendy Yen

AU - He, Tianyiyi

AU - Yen, Shih Cheng

AU - Thakor, Nitish V.

AU - Lee, Chengkuo

N1 - Funding Information: This work was supported by grants from the National Research Foundation (NRF) CRP project ‘Peripheral Nerve Prostheses: A Paradigm Shift in Restoring Dexterous Limb Function’ (R-719-000-001-281), and HIFES Seed Funding-2017-01 grant (R-263-501-012-133) “Hybrid Integration of Flexible Power Source and Pressure Sensors” at the National University of Singapore; The DGIST Start-up Fund Program of the Ministry of Science and ICT (2019010072), the National Research Foundation of Korea (2019R1C1C1008344). Funding Information: This work was supported by grants from the National Research Foundation (NRF) CRP project ‘Peripheral Nerve Prostheses: A Paradigm Shift in Restoring Dexterous Limb Function’ ( R-719-000-001-281 ), and HIFES Seed Funding-2017-01 grant ( R-263-501-012-133 ) “ Hybrid Integration of Flexible Power Source and Pressure Sensors ” at the National University of Singapore; The DGIST Start-up Fund Program of the Ministry of Science and ICT ( 2019010072 ), the National Research Foundation of Korea ( 2019R1C1C1008344 ). Publisher Copyright: © 2019

PY - 2019/6

Y1 - 2019/6

N2 - Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface. The detailed stimulation parameters such as current, pulse width, and charges generated by the proposed TENG were investigated for the stimulation of autonomic pelvic nerve. In in vivo experiments, different beats per minute (BPM) were delivered to the nerves to investigate the effect of stimulation frequency on mechano-neurostimulation while monitoring changes in bladder pressure and the occurrence of micturition. Furthermore, different numbers of pulses were applied to stimulate the pelvic nerve. The bladder contractions with micturition were observed when applying more than 50 BPM as well as one pulse. Comparison of stimulation was performed using a commercial stimulator with the similar long-pulse widths as generated by TENGs. In addition, chronic implantation of flexible clip interface was demonstrated with functionality test of the interface. The results demonstrate that this technology may potentially be used for self-powered mechano-neuromodulation for bladder function in the future.

AB - Mechano-neuromodulation of autonomic pelvic nerves was demonstrated for the first time using a triboelectric neurostimulator integrated with flexible neural clip interface. The detailed stimulation parameters such as current, pulse width, and charges generated by the proposed TENG were investigated for the stimulation of autonomic pelvic nerve. In in vivo experiments, different beats per minute (BPM) were delivered to the nerves to investigate the effect of stimulation frequency on mechano-neurostimulation while monitoring changes in bladder pressure and the occurrence of micturition. Furthermore, different numbers of pulses were applied to stimulate the pelvic nerve. The bladder contractions with micturition were observed when applying more than 50 BPM as well as one pulse. Comparison of stimulation was performed using a commercial stimulator with the similar long-pulse widths as generated by TENGs. In addition, chronic implantation of flexible clip interface was demonstrated with functionality test of the interface. The results demonstrate that this technology may potentially be used for self-powered mechano-neuromodulation for bladder function in the future.

KW - Mechano-neuromodulation

KW - Neural clip interface

KW - Pelvic nerve

KW - Triboelectric nanogenerator

KW - Underactive bladder

UR - http://www.scopus.com/inward/record.url?scp=85063632805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063632805&partnerID=8YFLogxK

U2 - 10.1016/j.nanoen.2019.03.082

DO - 10.1016/j.nanoen.2019.03.082

M3 - Article

AN - SCOPUS:85063632805

SN - 2211-2855

VL - 60

SP - 449

EP - 456

JO - Nano Energy

JF - Nano Energy

ER -

Mechano-neuromodulation of autonomic pelvic nerve for underactive bladder: A triboelectric neurostimulator integrated with flexible neural clip interface

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this