TY - JOUR
T1 - Mechanisms of vesicle docking and fusion
T2 - insights from the nervous system
AU - Pevsner, Jonathan
AU - Scheller, Richard H.
PY - 1994/8
Y1 - 1994/8
N2 - Upon stimulation of nerve cells, synaptic vesicles fuse with the presynaptic plasma membrane to release neurotransmitter. The biochemical pathway responsible for synaptic-vesicle docking and fusion is now being elucidated. Many of the proteins implicated in this process have homologs elsewhere in the cell. The docking and fusion mechanism discussed in this review may account for the specificity of vesicular trafficking throughout both regulated and constitutive secretory pathways.
AB - Upon stimulation of nerve cells, synaptic vesicles fuse with the presynaptic plasma membrane to release neurotransmitter. The biochemical pathway responsible for synaptic-vesicle docking and fusion is now being elucidated. Many of the proteins implicated in this process have homologs elsewhere in the cell. The docking and fusion mechanism discussed in this review may account for the specificity of vesicular trafficking throughout both regulated and constitutive secretory pathways.
UR - http://www.scopus.com/inward/record.url?scp=0028142137&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028142137&partnerID=8YFLogxK
U2 - 10.1016/0955-0674(94)90076-0
DO - 10.1016/0955-0674(94)90076-0
M3 - Article
C2 - 7986533
AN - SCOPUS:0028142137
SN - 0955-0674
VL - 6
SP - 555
EP - 560
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 4
ER -