Mechanisms of the blood-brain barrier disruption in HIV-1 infection

Michal Toborek; Yong Woo Lee; Govinder Flora; Hong Pu; Ibolya E. András; Edward Wylegala; Bernhard Hennig; Avindra Nath

doi:10.1007/s10571-004-1383-x

Mechanisms of the blood-brain barrier disruption in HIV-1 infection

Michal Toborek, Yong Woo Lee, Govinder Flora, Hong Pu, Ibolya E. András, Edward Wylegala, Bernhard Hennig, Avindra Nath

Research output: Contribution to journal › Review article › peer-review

167 Scopus citations

Abstract

1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

Original language	English (US)
Pages (from-to)	181-199
Number of pages	19
Journal	Cellular and molecular neurobiology
Volume	25
Issue number	1
DOIs	https://doi.org/10.1007/s10571-004-1383-x
State	Published - Feb 2005
Externally published	Yes

Keywords

AIDS
Blood-brain barrier
Brain endothelial cells
HIV
Inflammatory responses
Tat
Tight junction

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s10571-004-1383-x

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title = "Mechanisms of the blood-brain barrier disruption in HIV-1 infection",

abstract = "1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.",

keywords = "AIDS, Blood-brain barrier, Brain endothelial cells, HIV, Inflammatory responses, Tat, Tight junction",

author = "Michal Toborek and Lee, {Yong Woo} and Govinder Flora and Hong Pu and Andr{\'a}s, {Ibolya E.} and Edward Wylegala and Bernhard Hennig and Avindra Nath",

note = "Funding Information: This work was supported by NIH (NS39254, MH63022, and AA013843).",

year = "2005",

month = feb,

doi = "10.1007/s10571-004-1383-x",

language = "English (US)",

volume = "25",

pages = "181--199",

journal = "Cellular and molecular neurobiology",

issn = "0272-4340",

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T1 - Mechanisms of the blood-brain barrier disruption in HIV-1 infection

AU - Toborek, Michal

AU - Lee, Yong Woo

AU - Flora, Govinder

AU - Pu, Hong

AU - András, Ibolya E.

AU - Wylegala, Edward

AU - Hennig, Bernhard

AU - Nath, Avindra

N1 - Funding Information: This work was supported by NIH (NS39254, MH63022, and AA013843).

PY - 2005/2

Y1 - 2005/2

N2 - 1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

AB - 1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.

KW - AIDS

KW - Blood-brain barrier

KW - Brain endothelial cells

KW - HIV

KW - Inflammatory responses

KW - Tat

KW - Tight junction

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U2 - 10.1007/s10571-004-1383-x

DO - 10.1007/s10571-004-1383-x

M3 - Review article

C2 - 15962513

AN - SCOPUS:17644380598

SN - 0272-4340

VL - 25

SP - 181

EP - 199

JO - Cellular and molecular neurobiology

JF - Cellular and molecular neurobiology

IS - 1

ER -

Mechanisms of the blood-brain barrier disruption in HIV-1 infection

Abstract

Keywords

ASJC Scopus subject areas

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