Mechanisms of sarcoma development

Lee J. Helman, Paul Meltzer

Research output: Contribution to journalReview articlepeer-review

341 Scopus citations


Sarcomas are a rare and diverse group of tumours that are derived from connective tissues, including bone, muscle and cartilage. Although there are instances of hereditary predisposition to sarcomas, the overwhelming majority of such tumours are sporadic. In the past decade, we have gained much insight into the genetic abnormalities that seem to underlie the pathogenesis of these tumours. This information has already led to new classification of many sarcomas, as well as to successful therapies that are targeted at specific genetic abnormalities. It is likely that this approach will lead to continued refinements in classification and treatment of these tumours.

Original languageEnglish (US)
Pages (from-to)685-694
Number of pages10
JournalNature Reviews Cancer
Issue number9
StatePublished - Sep 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Mechanisms of sarcoma development'. Together they form a unique fingerprint.

Cite this