Mechanisms of recovery from aphasia: Evidence from serial xenon 133 cerebral blood flow studies

David S. Knopman, Alan B. Rubens, Ola A. Selnes, Arthur C. Klassen, Maurice W. Meyer

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


In 21 patients who suffered aphasia resulting from left hemisphere ischemic infarction, the xenon 133 inhalation cerebral blood flow techique was used to measure cerebral blood flow within 3 months and 5 to 12 months after stroke. In addition to baseline measurements, cerebral blood flow measurements were also carried out while the patients were performing purposeful listening. In patients with incomplete recovery of comprehension and left posterior temporal–inferior parietal lesions, greater cerebral blood flow occurred with listening in the right inferior frontal region in the late studies than in the early studies. In patients with nearly complete recovery of comprehension and without left posterior temporal–inferior parietal lesions, early listening studies showed diffuse right hemisphere increases in cerebral blood flow. Later listening studies in this latter patient group showed greater cerebral blood flow in the left posterior temporal–inferior parietal region. The study provides evidence for participation of the right hemisphere is language comprehension in recovering aphasics, and for later return of function in left hemisphere regions that may have been functionally impaired early during recovery.

Original languageEnglish (US)
Pages (from-to)530-535
Number of pages6
JournalAnnals of neurology
Issue number6
StatePublished - Jun 1984
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Mechanisms of recovery from aphasia: Evidence from serial xenon 133 cerebral blood flow studies'. Together they form a unique fingerprint.

Cite this