TY - JOUR
T1 - Mechanisms of Immune Evasion by Tumors
AU - Drake, Charles G.
AU - Jaffee, Elizabeth
AU - Pardoll, Drew M.
PY - 2006
Y1 - 2006
N2 - In the past decade, basic studies in animal models have begun to elucidate the physiological barriers which impede a successful antitumor immune response. These barriers operate at a number of levels, and involve the tumor, the tumor microenvironment and various components of the innate and adaptive immune systems. In this review, we discuss the multiple mechanisms by which tumors evade an immune response, with an emphasis on clinically relevant strategies to overcome these inhibitory checkpoints.
AB - In the past decade, basic studies in animal models have begun to elucidate the physiological barriers which impede a successful antitumor immune response. These barriers operate at a number of levels, and involve the tumor, the tumor microenvironment and various components of the innate and adaptive immune systems. In this review, we discuss the multiple mechanisms by which tumors evade an immune response, with an emphasis on clinically relevant strategies to overcome these inhibitory checkpoints.
UR - http://www.scopus.com/inward/record.url?scp=33646804507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646804507&partnerID=8YFLogxK
U2 - 10.1016/S0065-2776(06)90002-9
DO - 10.1016/S0065-2776(06)90002-9
M3 - Review article
C2 - 16730261
AN - SCOPUS:33646804507
SN - 0065-2776
VL - 90
SP - 51
EP - 81
JO - Advances in Immunology
JF - Advances in Immunology
ER -