Mechanisms of Autoimmunity

Research output: Chapter in Book/Report/Conference proceedingChapter


Autoimmune diseases encompass a broad spectrum of heterogeneous and complex disorders. Although the mechanistic underpinnings of most autoimmune diseases remain incompletely defined, much progress has been made in understanding the events that contribute to the development of the self-sustaining anti–host immune response that is the hallmark of rheumatic diseases. In this chapter, we will approach the mechanisms responsible for the development of autoimmunity by using the framework of distinct phases in the process of developing an autoimmune response; these phases include (i) susceptibility, (ii) initiation, (iii) propagation, and (iv) regulation/resolution.

Original languageEnglish (US)
Title of host publicationClinical Immunology
Subtitle of host publicationPrinciples and Practice
ISBN (Electronic)9780702068966
ISBN (Print)9780702070396
StatePublished - Jan 1 2019


  • Autoantigen
  • Autoimmunity
  • Initiation
  • Propagation
  • Regulation
  • Susceptibility
  • Tolerance

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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