Mechanisms for regulating deubiquitinating enzymes

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21 Scopus citations


Ubiquitination is a reversible post-translational modification that plays a dynamic role in regulating most eukaryotic processes. Deubiquitinating enzymes (DUBs), which hydrolyze the isopeptide or peptide linkages joining ubiquitin to substrate lysines or N-termini, therefore play a key role in ubiquitin signaling. Cells employ multiple mechanisms to regulate DUB activity and thus ensure the appropriate biological response. Recent structural studies have shed light on several different mechanisms by which DUB activity and specificity is regulated.

Original languageEnglish (US)
Pages (from-to)344-353
Number of pages10
JournalProtein Science
Issue number4
StatePublished - Apr 2014


  • DUB
  • Deubiquitinating enzymes
  • UBL
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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