Mechanism of action of antitumor drug etoposide: A review

J. M S Van Maanen; J. Retèl; J. De Vries; H. M. Pinedo

doi:10.1093/jnci/80.19.1526

Mechanism of action of antitumor drug etoposide: A review

J. M S Van Maanen, J. Retèl, J. De Vries, H. M. Pinedo

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245 Scopus citations

Abstract

Metabolism studies of the antitumor drug etoposide show the formation of metabolites in the lactone ring, which are probably not important for the drug's mechanism of action, and oxidative transformations in the dimethoxyphenol ring (E ring), which lead to products that can cause DNA damage and may play a role in the drug's mechanism of action. The cytotoxicity of etoposide is caused by the induction of DNA damage. The occurrence of the DNA lesions can be explained by the capacity of the drug to interfere with the scission-reunion reaction of mammalian topoisomerase II by stabilizing a cleavable complex. [ Natl Cancer Inst 1988;80:1526-1533].

Original language	English (US)
Pages (from-to)	1526-1533
Number of pages	8
Journal	Journal of the National Cancer Institute
Volume	80
Issue number	19
DOIs	https://doi.org/10.1093/jnci/80.19.1526
State	Published - Jul 7 1988
Externally published	Yes

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Physiology (medical)
Radiology Nuclear Medicine and imaging
Oncology
Cancer Research

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10.1093/jnci/80.19.1526

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abstract = "Metabolism studies of the antitumor drug etoposide show the formation of metabolites in the lactone ring, which are probably not important for the drug's mechanism of action, and oxidative transformations in the dimethoxyphenol ring (E ring), which lead to products that can cause DNA damage and may play a role in the drug's mechanism of action. The cytotoxicity of etoposide is caused by the induction of DNA damage. The occurrence of the DNA lesions can be explained by the capacity of the drug to interfere with the scission-reunion reaction of mammalian topoisomerase II by stabilizing a cleavable complex. [ Natl Cancer Inst 1988;80:1526-1533].",

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AU - Van Maanen, J. M S

AU - Retèl, J.

AU - De Vries, J.

AU - Pinedo, H. M.

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AB - Metabolism studies of the antitumor drug etoposide show the formation of metabolites in the lactone ring, which are probably not important for the drug's mechanism of action, and oxidative transformations in the dimethoxyphenol ring (E ring), which lead to products that can cause DNA damage and may play a role in the drug's mechanism of action. The cytotoxicity of etoposide is caused by the induction of DNA damage. The occurrence of the DNA lesions can be explained by the capacity of the drug to interfere with the scission-reunion reaction of mammalian topoisomerase II by stabilizing a cleavable complex. [ Natl Cancer Inst 1988;80:1526-1533].

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Mechanism of action of antitumor drug etoposide: A review

Abstract

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