Mechanism and Regulation of Centriole and Cilium Biogenesis

David K. Breslow, Andrew J. Holland

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The centriole is an ancient microtubule-based organelle with a conserved nine-fold symmetry. Centrioles form the core of centrosomes, which organize the interphase microtubule cytoskeleton of most animal cells and form the poles of the mitotic spindle. Centrioles can also be modified to form basal bodies, which template the formation of cilia and play central roles in cellular signaling, fluid movement, and locomotion. In this review, we discuss developments in our understanding of the biogenesis of centrioles and cilia and the regulatory controls that govern their structure and number. We also discuss how defects in these processes contribute to a spectrum of human diseases and how new technologies have expanded our understanding of centriole and cilium biology, revealing exciting avenues for future exploration.

Original languageEnglish (US)
Pages (from-to)691-724
Number of pages34
JournalAnnual review of biochemistry
StatePublished - Jun 20 2019


  • cell cycle
  • centriole
  • centrosome
  • cilia
  • ciliopathy
  • mitosis

ASJC Scopus subject areas

  • Biochemistry


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