Mechanism and prevention of ischemia/reperfusion injury in island skin flaps

K. K. Narayan; M. J. Im; P. N. Manson

Mechanism and prevention of ischemia/reperfusion injury in island skin flaps

K. K. Narayan, M. J. Im, P. N. Manson

School of Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We have demonstrated that treatment with either superoxide dismutase, a scavenger of superoxide radicals, or allopurinol, an inhibitor of xanthine oxidase, significantly increases the survival of island skin flaps following ischemia. We further investigated the mechanism of ischemia/reperfusion injury following a prolonged arteriovenous occlusion in island skin flaps in rats.

Original language	English (US)
Pages (from-to)	593-595
Number of pages	3
Journal	Surgical forum
Volume	VOL. 36
State	Published - Jan 1 1985

ASJC Scopus subject areas

Surgery

Cite this

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title = "Mechanism and prevention of ischemia/reperfusion injury in island skin flaps",

abstract = "We have demonstrated that treatment with either superoxide dismutase, a scavenger of superoxide radicals, or allopurinol, an inhibitor of xanthine oxidase, significantly increases the survival of island skin flaps following ischemia. We further investigated the mechanism of ischemia/reperfusion injury following a prolonged arteriovenous occlusion in island skin flaps in rats.",

author = "Narayan, {K. K.} and Im, {M. J.} and Manson, {P. N.}",

year = "1985",

month = jan,

day = "1",

language = "English (US)",

volume = "VOL. 36",

pages = "593--595",

journal = "Surgical forum",

issn = "0071-8041",

publisher = "American College of Surgeons",

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T1 - Mechanism and prevention of ischemia/reperfusion injury in island skin flaps

AU - Narayan, K. K.

AU - Im, M. J.

AU - Manson, P. N.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - We have demonstrated that treatment with either superoxide dismutase, a scavenger of superoxide radicals, or allopurinol, an inhibitor of xanthine oxidase, significantly increases the survival of island skin flaps following ischemia. We further investigated the mechanism of ischemia/reperfusion injury following a prolonged arteriovenous occlusion in island skin flaps in rats.

AB - We have demonstrated that treatment with either superoxide dismutase, a scavenger of superoxide radicals, or allopurinol, an inhibitor of xanthine oxidase, significantly increases the survival of island skin flaps following ischemia. We further investigated the mechanism of ischemia/reperfusion injury following a prolonged arteriovenous occlusion in island skin flaps in rats.

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UR - http://www.scopus.com/inward/citedby.url?scp=0022358019&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0022358019

SN - 0071-8041

VL - VOL. 36

SP - 593

EP - 595

JO - Surgical forum

JF - Surgical forum

ER -

Mechanism and prevention of ischemia/reperfusion injury in island skin flaps

Abstract

ASJC Scopus subject areas

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