Mechanics and regulation of cytokinesis

Douglas N. Robinson; James A. Spudich

doi:10.1016/j.ceb.2004.02.002

Mechanics and regulation of cytokinesis

Douglas N. Robinson, James A. Spudich

School of Medicine

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Recent advances are revealing quantitative aspects of cytokinesis. Further, genetic analyses and cell imaging are providing insights into the molecular dynamics of cleavage furrow ingression as well as further refining our knowledge of the zones of the mitotic spindle that regulate the contractile properties of the overlying cortex. Ultimately, however, cortical mechanics are the result of signals that emanate from the mitotic spindle. A genuine quantitative understanding of cytokinesis must include a thorough analysis of the mechanical properties of the cortex and how signals modify these properties to dictate a well-controlled, error-free cytokinesis.

Original language	English (US)
Pages (from-to)	182-188
Number of pages	7
Journal	Current Opinion in Cell Biology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.ceb.2004.02.002
State	Published - Apr 2004

Keywords

Arp2/3
F
FRET
Force
MHCK
MKLP
MLCK
PCH
PLK1
Polo-like kinase 1
R
actin-related protein 2/3
fluorescence resonance energy transfer
mitotic kinesin-like protein
myosin-II heavy chain kinase
myosin-II light chain kinase
pombe Cdc15 homology

ASJC Scopus subject areas

Cell Biology

Access to Document

10.1016/j.ceb.2004.02.002

Cite this

@article{2b83285a3f3442499029f28b8f1451ea,

title = "Mechanics and regulation of cytokinesis",

abstract = "Recent advances are revealing quantitative aspects of cytokinesis. Further, genetic analyses and cell imaging are providing insights into the molecular dynamics of cleavage furrow ingression as well as further refining our knowledge of the zones of the mitotic spindle that regulate the contractile properties of the overlying cortex. Ultimately, however, cortical mechanics are the result of signals that emanate from the mitotic spindle. A genuine quantitative understanding of cytokinesis must include a thorough analysis of the mechanical properties of the cortex and how signals modify these properties to dictate a well-controlled, error-free cytokinesis.",

keywords = "Arp2/3, F, FRET, Force, MHCK, MKLP, MLCK, PCH, PLK1, Polo-like kinase 1, R, actin-related protein 2/3, fluorescence resonance energy transfer, mitotic kinesin-like protein, myosin-II heavy chain kinase, myosin-II light chain kinase, pombe Cdc15 homology",

author = "Robinson, {Douglas N.} and Spudich, {James A.}",

year = "2004",

month = apr,

doi = "10.1016/j.ceb.2004.02.002",

language = "English (US)",

volume = "16",

pages = "182--188",

journal = "Current Opinion in Cell Biology",

issn = "0955-0674",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Mechanics and regulation of cytokinesis

AU - Robinson, Douglas N.

AU - Spudich, James A.

PY - 2004/4

Y1 - 2004/4

N2 - Recent advances are revealing quantitative aspects of cytokinesis. Further, genetic analyses and cell imaging are providing insights into the molecular dynamics of cleavage furrow ingression as well as further refining our knowledge of the zones of the mitotic spindle that regulate the contractile properties of the overlying cortex. Ultimately, however, cortical mechanics are the result of signals that emanate from the mitotic spindle. A genuine quantitative understanding of cytokinesis must include a thorough analysis of the mechanical properties of the cortex and how signals modify these properties to dictate a well-controlled, error-free cytokinesis.

AB - Recent advances are revealing quantitative aspects of cytokinesis. Further, genetic analyses and cell imaging are providing insights into the molecular dynamics of cleavage furrow ingression as well as further refining our knowledge of the zones of the mitotic spindle that regulate the contractile properties of the overlying cortex. Ultimately, however, cortical mechanics are the result of signals that emanate from the mitotic spindle. A genuine quantitative understanding of cytokinesis must include a thorough analysis of the mechanical properties of the cortex and how signals modify these properties to dictate a well-controlled, error-free cytokinesis.

KW - Arp2/3

KW - F

KW - FRET

KW - Force

KW - MHCK

KW - MKLP

KW - MLCK

KW - PCH

KW - PLK1

KW - Polo-like kinase 1

KW - R

KW - actin-related protein 2/3

KW - fluorescence resonance energy transfer

KW - mitotic kinesin-like protein

KW - myosin-II heavy chain kinase

KW - myosin-II light chain kinase

KW - pombe Cdc15 homology

UR - http://www.scopus.com/inward/record.url?scp=2942661593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2942661593&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2004.02.002

DO - 10.1016/j.ceb.2004.02.002

M3 - Review article

C2 - 15196562

AN - SCOPUS:2942661593

SN - 0955-0674

VL - 16

SP - 182

EP - 188

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 2

ER -

Mechanics and regulation of cytokinesis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this