Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla

Nicolaas A.J. Puts; Peter B. Barker; Richard A.E. Edden

doi:10.1002/jmri.23817

Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla

Nicolaas A.J. Puts, Peter B. Barker, Richard A.E. Edden

School of Medicine

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Purpose: To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T). Materials and Methods: J-difference edited single-voxel MR spectroscopy was used to isolate γ-aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data. Results: The longitudinal relaxation time of GABA was measured as T_1,GABA = 1.31 ± 0.16 s. Conclusion: The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.

Original language	English (US)
Pages (from-to)	999-1003
Number of pages	5
Journal	Journal of Magnetic Resonance Imaging
Volume	37
Issue number	4
DOIs	https://doi.org/10.1002/jmri.23817
State	Published - Apr 2013

Keywords

3T
GABA
MEGA-PRESS
MRS
T1 relaxation
macromolecules

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/jmri.23817

Cite this

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abstract = "Purpose: To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T). Materials and Methods: J-difference edited single-voxel MR spectroscopy was used to isolate γ-aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data. Results: The longitudinal relaxation time of GABA was measured as T1,GABA = 1.31 ± 0.16 s. Conclusion: The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.",

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AU - Barker, Peter B.

AU - Edden, Richard A.E.

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N2 - Purpose: To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T). Materials and Methods: J-difference edited single-voxel MR spectroscopy was used to isolate γ-aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data. Results: The longitudinal relaxation time of GABA was measured as T1,GABA = 1.31 ± 0.16 s. Conclusion: The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.

AB - Purpose: To measure the in vivo longitudinal relaxation time T1 of GABA at 3 Tesla (T). Materials and Methods: J-difference edited single-voxel MR spectroscopy was used to isolate γ-aminobutyric acid (GABA) signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in 10 healthy participants, a saturation-recovery equation was used to model the integrated data. Results: The longitudinal relaxation time of GABA was measured as T1,GABA = 1.31 ± 0.16 s. Conclusion: The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.

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Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla

Abstract

Keywords

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