Measuring the Functioning Human Brain

Martin A. Lindquist; Bonnie B. Smith; Arunkumar Kannan; Angela Zhao; Brian Caffo

doi:10.1146/annurev-statistics-040522-100329

Measuring the Functioning Human Brain

Martin A. Lindquist, Bonnie B. Smith, Arunkumar Kannan, Angela Zhao, Brian Caffo

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

The emergence of functional magnetic resonance imaging (fMRI) marked a significant technological breakthrough in the real-time measurement of the functioning human brain in vivo. In part because of their 4D nature (three spatial dimensions and time), fMRI data have inspired a great deal of statistical development in the past couple of decades to address their unique spatiotemporal properties. This article provides an overview of the current landscape in functional brain measurement, with a particular focus on fMRI, highlighting key developments in the past decade. Furthermore, it looks ahead to the future, discussing unresolved research questions in the community and outlining potential research topics for the future.

Original language	English (US)
Pages (from-to)	283-309
Number of pages	27
Journal	Annual Review of Statistics and Its Application
Volume	12
Issue number	1
DOIs	https://doi.org/10.1146/annurev-statistics-040522-100329
State	Published - Mar 7 2025

Keywords

brain
connectivity
fMRI
functional magnetic resonance imaging
prediction
resting-state fMRI
statistics

ASJC Scopus subject areas

Statistics and Probability
Statistics, Probability and Uncertainty

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10.1146/annurev-statistics-040522-100329

Cite this

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AU - Zhao, Angela

AU - Caffo, Brian

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AB - The emergence of functional magnetic resonance imaging (fMRI) marked a significant technological breakthrough in the real-time measurement of the functioning human brain in vivo. In part because of their 4D nature (three spatial dimensions and time), fMRI data have inspired a great deal of statistical development in the past couple of decades to address their unique spatiotemporal properties. This article provides an overview of the current landscape in functional brain measurement, with a particular focus on fMRI, highlighting key developments in the past decade. Furthermore, it looks ahead to the future, discussing unresolved research questions in the community and outlining potential research topics for the future.

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KW - prediction

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Measuring the Functioning Human Brain

Abstract

Keywords

ASJC Scopus subject areas

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