Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method

Jan H. Hoh; Paul E. Hillner; Paul K. Hansma

Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method

Jan H. Hoh, Paul E. Hillner, Paul K. Hansma

School of Medicine

Research output: Contribution to conference › Paper › peer-review

6 Scopus citations

Abstract

A novel approach to measuring intermolecular forces with the atomic force microscope (AFM) that employs paramagnetic beads coated with one of the molecules to be studied is presented. The magnetic jump method for measuring intermolecular forces utilizes commercially available paramagnetic beads that are supplied in a variety of sizes with several well-defined and convenient coupling chemistries. Its principle is that the measured binding force will depend on the gradient of the external force applied to the bond. The magnetic interaction determines the external force applied gradient which can be several orders of magnitude smaller than the AFM cantilever force gradient.

Original language	English (US)
Pages	1054-1055
Number of pages	2
State	Published - Dec 1 1994
Event	Proceedings of the 52nd Annual Meeting of the Microscopy Society of America - New Orleans, LA, USA Duration: Jul 31 1994 → Aug 5 1994

Other

Other	Proceedings of the 52nd Annual Meeting of the Microscopy Society of America
City	New Orleans, LA, USA
Period	7/31/94 → 8/5/94

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method",

abstract = "A novel approach to measuring intermolecular forces with the atomic force microscope (AFM) that employs paramagnetic beads coated with one of the molecules to be studied is presented. The magnetic jump method for measuring intermolecular forces utilizes commercially available paramagnetic beads that are supplied in a variety of sizes with several well-defined and convenient coupling chemistries. Its principle is that the measured binding force will depend on the gradient of the external force applied to the bond. The magnetic interaction determines the external force applied gradient which can be several orders of magnitude smaller than the AFM cantilever force gradient.",

author = "Hoh, {Jan H.} and Hillner, {Paul E.} and Hansma, {Paul K.}",

year = "1994",

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language = "English (US)",

pages = "1054--1055",

note = "Proceedings of the 52nd Annual Meeting of the Microscopy Society of America ; Conference date: 31-07-1994 Through 05-08-1994",

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T1 - Measuring intermolecular binding forces with the atomic-force microscope

T2 - Proceedings of the 52nd Annual Meeting of the Microscopy Society of America

AU - Hoh, Jan H.

AU - Hillner, Paul E.

AU - Hansma, Paul K.

PY - 1994/12/1

Y1 - 1994/12/1

N2 - A novel approach to measuring intermolecular forces with the atomic force microscope (AFM) that employs paramagnetic beads coated with one of the molecules to be studied is presented. The magnetic jump method for measuring intermolecular forces utilizes commercially available paramagnetic beads that are supplied in a variety of sizes with several well-defined and convenient coupling chemistries. Its principle is that the measured binding force will depend on the gradient of the external force applied to the bond. The magnetic interaction determines the external force applied gradient which can be several orders of magnitude smaller than the AFM cantilever force gradient.

AB - A novel approach to measuring intermolecular forces with the atomic force microscope (AFM) that employs paramagnetic beads coated with one of the molecules to be studied is presented. The magnetic jump method for measuring intermolecular forces utilizes commercially available paramagnetic beads that are supplied in a variety of sizes with several well-defined and convenient coupling chemistries. Its principle is that the measured binding force will depend on the gradient of the external force applied to the bond. The magnetic interaction determines the external force applied gradient which can be several orders of magnitude smaller than the AFM cantilever force gradient.

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Y2 - 31 July 1994 through 5 August 1994

ER -

Measuring intermolecular binding forces with the atomic-force microscope: The magnetic jump method

Abstract

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ASJC Scopus subject areas

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