TY - JOUR
T1 - Measurement of the risk for substance use disorders
T2 - Phenotypic and genetic analysis of an index of common liability
AU - Vanyukov, Michael M.
AU - Kirisci, Levent
AU - Moss, Lisa
AU - Tarter, Ralph E.
AU - Reynolds, Maureen D.
AU - Maher, Brion S.
AU - Kirillova, Galina P.
AU - Ridenour, Ty
AU - Clark, Duncan B.
N1 - Funding Information:
Acknowledgments The authors are indebted to the staff of the Center for Education and Drug Abuse Research, University of Pittsburgh, for their effort and dedication. This study was supported by the National Institute on Drug Abuse grants P50DA005605, R01DA011922, R01DA019157, K02DA018701, K02DA017822, and the National Institute on Alcohol Abuse and Alcoholism grant K02AA00296
PY - 2009/5
Y1 - 2009/5
N2 - The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI's phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.
AB - The inability to quantify the risk for disorders, such as substance use disorders (SUD), hinders etiology research and development of targeted intervention. Based on the concept of common transmissible liability to SUD related to illicit drugs, a method enabling quantification of this latent trait has been developed, utilizing high-risk design and item response theory. This study examined properties of a SUD transmissible liability index (TLI) derived using this method. Sons of males with or without SUD were studied longitudinally from preadolescence to young adulthood. The properties of TLI, including its psychometric characteristics, longitudinal risk assessment and ethnic variation, were examined. A pilot twin study was conducted to analyze the composition of TLI's phenotypic variance. The data suggest that TLI has concurrent, incremental, predictive and discriminant validity, as well as ethnic differences. The data suggest a high heritability of the index in males. The results suggest applicability of the method for genetic and other etiology-related research, and for evaluation of individual risk.
KW - Addiction
KW - Ethnicity
KW - IRT
KW - Phenotype
KW - Race
KW - Transmissibility
UR - http://www.scopus.com/inward/record.url?scp=67349092930&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349092930&partnerID=8YFLogxK
U2 - 10.1007/s10519-009-9269-9
DO - 10.1007/s10519-009-9269-9
M3 - Article
C2 - 19377872
AN - SCOPUS:67349092930
SN - 0001-8244
VL - 39
SP - 233
EP - 244
JO - Behavior Genetics
JF - Behavior Genetics
IS - 3
ER -