TY - JOUR
T1 - Measurement of plasma viscosity in stored frozen samples
T2 - A general population study
AU - Woodward, Mark
AU - Lowe, Gordon
AU - Rumley, Ann
AU - Imhof, Armin
AU - Koenig, Wolfgang
PY - 2003/6
Y1 - 2003/6
N2 - To establish whether plasma viscosity could be accurately measured from frozen-stored (instead of fresh) plasma samples in epidemiological studies, we prospectively compared fresh and frozen-stored samples from 1361 men and women aged 25-74 years participating in the Glasgow MONICA survey. Mean plasma viscosity (37°C) was significantly higher (P < 0.0001) in fresh samples (mean = 1.310 mPa/s, standard deviation = 0.079 mPa/s) compared with frozen samples (mean = 1.278 mPa/s, standard deviation = 0.075 mPa/s). However, this difference (mean = 0.030 mPa/s, 95% confidence interval = 0.029-0.031) did not vary significantly with increasing viscosity (kappa statistic for consistency of categorization by thirds = 0.824, standard error = 0.021). We conclude that frozen samples are acceptable for epidemiological studies of plasma viscosity, which should increase their utilization.
AB - To establish whether plasma viscosity could be accurately measured from frozen-stored (instead of fresh) plasma samples in epidemiological studies, we prospectively compared fresh and frozen-stored samples from 1361 men and women aged 25-74 years participating in the Glasgow MONICA survey. Mean plasma viscosity (37°C) was significantly higher (P < 0.0001) in fresh samples (mean = 1.310 mPa/s, standard deviation = 0.079 mPa/s) compared with frozen samples (mean = 1.278 mPa/s, standard deviation = 0.075 mPa/s). However, this difference (mean = 0.030 mPa/s, 95% confidence interval = 0.029-0.031) did not vary significantly with increasing viscosity (kappa statistic for consistency of categorization by thirds = 0.824, standard error = 0.021). We conclude that frozen samples are acceptable for epidemiological studies of plasma viscosity, which should increase their utilization.
KW - Coronary heart disease
KW - Epidemiology
KW - Viscosity
UR - http://www.scopus.com/inward/record.url?scp=0038509100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038509100&partnerID=8YFLogxK
U2 - 10.1097/00001721-200306000-00015
DO - 10.1097/00001721-200306000-00015
M3 - Article
C2 - 12945886
AN - SCOPUS:0038509100
SN - 0957-5235
VL - 14
SP - 417
EP - 420
JO - Blood Coagulation and Fibrinolysis
JF - Blood Coagulation and Fibrinolysis
IS - 4
ER -