Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection

Albert Vexler; Aiyi Liu; Ekaterina Eliseeva; Enrique F. Schisterman

doi:10.1111/j.1541-0420.2007.00941.x

Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection

Albert Vexler, Aiyi Liu, Ekaterina Eliseeva, Enrique F. Schisterman

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.

Original language	English (US)
Pages (from-to)	895-903
Number of pages	9
Journal	Biometrics
Volume	64
Issue number	3
DOIs	https://doi.org/10.1111/j.1541-0420.2007.00941.x
State	Published - Sep 2008
Externally published	Yes

Keywords

Area under curve (AUC)
Censoring
Hypothesis testing
Limit of detection (LOD)
Maximum likelihood
Receiver operating characteristics (ROC)

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Applied Mathematics
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Statistics and Probability

Access to Document

10.1111/j.1541-0420.2007.00941.x

Cite this

@article{d30698b5aae74c9b96571a228db49f1a,

title = "Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection",

abstract = "In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.",

keywords = "Area under curve (AUC), Censoring, Hypothesis testing, Limit of detection (LOD), Maximum likelihood, Receiver operating characteristics (ROC)",

author = "Albert Vexler and Aiyi Liu and Ekaterina Eliseeva and Schisterman, {Enrique F.}",

year = "2008",

month = sep,

doi = "10.1111/j.1541-0420.2007.00941.x",

language = "English (US)",

volume = "64",

pages = "895--903",

journal = "Biometrics",

issn = "0006-341X",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection

AU - Vexler, Albert

AU - Liu, Aiyi

AU - Eliseeva, Ekaterina

AU - Schisterman, Enrique F.

PY - 2008/9

Y1 - 2008/9

N2 - In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.

AB - In this article, we consider comparing the areas under correlated receiver operating characteristic (ROC) curves of diagnostic biomarkers whose measurements are subject to a limit of detection (LOD), a source of measurement error from instruments' sensitivity in epidemiological studies. We propose and examine the likelihood ratio tests with operating characteristics that are easily obtained by classical maximum likelihood methodology.

KW - Area under curve (AUC)

KW - Censoring

KW - Hypothesis testing

KW - Limit of detection (LOD)

KW - Maximum likelihood

KW - Receiver operating characteristics (ROC)

UR - http://www.scopus.com/inward/record.url?scp=49749130404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49749130404&partnerID=8YFLogxK

U2 - 10.1111/j.1541-0420.2007.00941.x

DO - 10.1111/j.1541-0420.2007.00941.x

M3 - Article

C2 - 18047527

AN - SCOPUS:49749130404

SN - 0006-341X

VL - 64

SP - 895

EP - 903

JO - Biometrics

JF - Biometrics

IS - 3

ER -

Maximum likelihood ratio tests for comparing the discriminatory ability of biomarkers subject to limit of detection

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this