Maturation of Tertiary Lymphoid Structures

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tertiary lymphoid structures (TLS) are organized collections of B and T lymphocytes that arise in nonlymphoid tissue in response to chronic, unresolved inflammation. TLS have structural and functional similarities to germinal centers found in lymph nodes and are believed to support the establishment of lymph node-like adaptive immune responses at local sites of inflammation. However, understanding of the underlying biology of these structures remains limited, particularly the different stages of TLS life cycle and the signals governing the initiation, maturation, and termination of TLS. Here, we review current understanding of the maturation of TLS and the signals and cell types involved in various stages of development with particular emphasis on recent studies of TLS in cancer, where evidence suggests that TLS may play an important role in supporting antitumor immune responses in solid tumors.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages43-55
Number of pages13
DOIs
StatePublished - 2025

Publication series

NameMethods in Molecular Biology
Volume2864
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • CCL19
  • CCL21
  • CXCL13
  • Follicular dendritic cell
  • High endothelial venule
  • Lymphoid aggregate
  • Lymphotoxin
  • Tertiary lymphoid organ
  • Tertiary lymphoid structure

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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