Matrix metalloproteinases and the regulation of tissue remodelling

Andrea Page-McCaw, Andrew J. Ewald, Zena Werb

Research output: Contribution to journalReview articlepeer-review

1930 Scopus citations


Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

Original languageEnglish (US)
Pages (from-to)221-233
Number of pages13
JournalNature Reviews Molecular Cell Biology
Issue number3
StatePublished - Mar 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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