Maternal postpartum plasma folate status and preterm birth in a high-risk US population

Bolanle Olapeju, Ahmed Saifuddin, Guoying Wang, Yuelong Ji, Xiumei Hong, Ramkripa Raghavan, Amber Summers, Amaris Keiser, Hongkai Ji, Barry Zuckerman, Christina Yarrington, Lingxin Hao, Pamela J. Surkan, Tina L. Cheng, Xiaobin Wang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Objective: While maternal folate deficiency has been linked to poor pregnancy outcomes such as neural tube defects, anaemia and low birth weight, the relationship between folate and preterm birth (PTB) in the context of the US post-folic acid fortification era is inconclusive. We sought to explore the relationship between maternal folate status and PTB and its subtypes, i.e. spontaneous and medically indicated PTB. Design: Observational study. Setting: Boston Birth Cohort, a predominantly urban, low-income, race/ethnic minority population at a high risk for PTB. Participants: Mother-infant dyads (n 7675) enrolled in the Boston Birth Cohort. A sub-sample (n 2313) of these dyads had maternal plasma folate samples collected 24-72 h after delivery. Results: Unadjusted and adjusted logistic regressions revealed an inverse relationship between the frequency of multivitamin supplement intake and PTB. Compared with less frequent use, multivitamin supplement intake 3-5 times/week (adjusted OR (aOR) = 0.78; 95 % CI 0.64, 0.96) or >5 times/week (aOR = 0.77; 95 % CI 0.64, 0.93) throughout pregnancy was associated with reduced risk of PTB. Consistently, higher plasma folate levels (highest v. lowest quartile) were associated with lower risk of PTB (aOR = 0.74; 95 % CI 0.56, 0.97). The above associations were similar among spontaneous and medically indicated PTB. Conclusions: If confirmed by future studies, our findings raise the possibility that optimizing maternal folate levels across pregnancy may help to reduce the risk of PTB among the most vulnerable US population in the post-folic acid fortification era.

Original languageEnglish (US)
Pages (from-to)1281-1291
Number of pages11
JournalPublic health nutrition
Issue number7
StatePublished - May 1 2019


  • Folate status
  • Multivitamin supplementation
  • Preterm birth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Maternal postpartum plasma folate status and preterm birth in a high-risk US population'. Together they form a unique fingerprint.

Cite this