@article{da36aca343344309a3bee5c8f5f230c8,
title = "Maternal Exposure to Occupational Asthmagens During Pregnancy and Autism Spectrum Disorder in the Study to Explore Early Development",
abstract = "Maternal immune activity has been linked to children with autism spectrum disorder (ASD). We examined maternal occupational exposure to asthma-causing agents during pregnancy in relation to ASD risk. Our sample included 463 ASD cases and 710 general population controls from the Study to Explore Early Development whose mothers reported at least one job during pregnancy. Asthmagen exposure was estimated from a published job-exposure matrix. The adjusted odds ratio for ASD comparing asthmagen-exposed to unexposed was 1.39 (95 % CI 0.96–2.02). Maternal workplace asthmagen exposure was not associated with ASD risk in this study, but this result does not exclude some involvement of maternal exposure to asthma-causing agents in ASD.",
keywords = "Allergy, Asthma, Autism, Exposure, Maternal, Maternal occupation",
author = "Singer, {Alison B.} and Windham, {Gayle C.} and Croen, {Lisa A.} and Daniels, {Julie L.} and Lee, {Brian K.} and Yinge Qian and Schendel, {Diana E.} and Fallin, {M. Daniele} and Igor Burstyn",
note = "Funding Information: Alison B. Singer was funded by an Autism Speaks Dennis Weatherstone Predoctoral Fellowship (#8576) and by NIEHS T32ES007018. The Study to Explore Early Development was funded by six cooperative agreements from the Centers for Disease Control and Prevention: Cooperative Agreement Number U10DD000180, Colorado Department of Public Health; Cooperative Agreement Number U10DD000181, Kaiser Foundation Research Institute (CA); Cooperative Agreement Number U10DD000182, University of Pennsylvania; Cooperative Agreement Number U10DD000183, Johns Hopkins University; Cooperative Agreement Number U10DD000184, University of North Carolina at Chapel Hill; and Cooperative Agreement Number U10DD000498, Michigan State University. An earlier version of these findings was presented as a poster at the International Meeting for Autism Research in Atlanta, Georgia on May 15, 2014 and was included in the doctoral dissertation of Alison B. Singer at the Johns Hopkins University dated April 2015. We also acknowledge Carolyn DiGuiseppi, Gnakub Norbert Soke, Eric Rubenstein, and Aimee Alexander for assistance with data cleaning. Some of this data was supplied by the Bureau of Health Statistics and Research—PA Department of Health Harrisburg, PA. The PA Department of Health specifically disclaims responsibility for any analysis interpretations or conclusions. Publisher Copyright: {\textcopyright} 2016, The Author(s).",
year = "2016",
month = nov,
day = "1",
doi = "10.1007/s10803-016-2882-6",
language = "English (US)",
volume = "46",
pages = "3458--3468",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",
number = "11",
}