TY - JOUR
T1 - Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder
T2 - Evidence of Sex Difference
AU - Panjwani, Anita A.
AU - Ji, Yuelong
AU - Fahey, Jed W
AU - Palmer, Amanda
AU - Wang, Guoying
AU - Hong, Xiumei
AU - Zuckerman, Barry
AU - Wang, Xiaobin
N1 - Funding Information:
The authors would like to thank all the study participants and staff as the study would not have been possible without their support and participation. This work is supported by the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (HHS) under Grant Numbers R40MC27443 and UJ2MC31074. The Boston Birth Cohort (parent study) is supported in part by the March of Dimes PERI Grants (20-FY02-56, #21-FY07-605); and the National Institutes of Health (NIH) Grants (R21ES011666, 2R01HD041702, R21HD066471, U01AI090727, R21AI079872, and R01HD086013). This information or content and conclusions are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by HRSA, HHS, or the U.S. Government. The authors do not have any conflicts of interest to disclose.
Funding Information:
The authors would like to thank all the study participants and staff as the study would not have been possible without their support and participation. This work is supported by the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (HHS) under Grant Numbers R40MC27443 and UJ2MC31074. The Boston Birth Cohort (parent study) is supported in part by the March of Dimes PERI Grants (20-FY02-56, #21-FY07-605); and the National Institutes of Health (NIH) Grants (R21ES011666, 2R01HD041702, R21HD066471, U01AI090727, R21AI079872, and R01HD086013). This information or content and conclusions are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by HRSA, HHS, or the U.S. Government. The authors do not have any conflicts of interest to disclose.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2020/2/1
Y1 - 2020/2/1
N2 - In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), the roles of maternal dyslipidemia and sex disparity in ASD have not been well-studied. We examined the joint associations of maternal plasma cholesterols, branched-chain amino acids (BCAAs) and child sex on child ASD risk. We analyzed data from 756 mother-infant pairs (86 ASD) from the Boston Birth Cohort. Maternal plasma cholesterols and BCAAs were measured in samples collected 24–72 h postpartum. We found that in this urban, low-income prospective birth cohort, low maternal high-density lipoprotein cholesterol (HDL-C), above-median maternal plasma BCAA concentrations, and male sex additively or synergistically increased risk of ASD. Additional studies are necessary to confirm our findings.
AB - In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), the roles of maternal dyslipidemia and sex disparity in ASD have not been well-studied. We examined the joint associations of maternal plasma cholesterols, branched-chain amino acids (BCAAs) and child sex on child ASD risk. We analyzed data from 756 mother-infant pairs (86 ASD) from the Boston Birth Cohort. Maternal plasma cholesterols and BCAAs were measured in samples collected 24–72 h postpartum. We found that in this urban, low-income prospective birth cohort, low maternal high-density lipoprotein cholesterol (HDL-C), above-median maternal plasma BCAA concentrations, and male sex additively or synergistically increased risk of ASD. Additional studies are necessary to confirm our findings.
KW - Autism spectrum disorder
KW - Branched-chain amino acids
KW - Maternal cholesterols
KW - Metabolomics
KW - Pre- and perinatal risk factors
KW - Sex differences
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UR - http://www.scopus.com/inward/citedby.url?scp=85074747648&partnerID=8YFLogxK
U2 - 10.1007/s10803-019-04264-x
DO - 10.1007/s10803-019-04264-x
M3 - Article
C2 - 31686281
AN - SCOPUS:85074747648
SN - 0162-3257
VL - 50
SP - 540
EP - 550
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 2
ER -