Matching ATP supply and demand in mammalian heart: In vivo, in vitro, and in silico perspectives

Yael Yaniv; Magdalena Juhaszova; H. Bradley Nuss; Su Wang; Dmitry B. Zorov; Edward G. Lakatta; Steven J. Sollott

doi:10.1111/j.1749-6632.2009.05093.x

Matching ATP supply and demand in mammalian heart: In vivo, in vitro, and in silico perspectives

Yael Yaniv, Magdalena Juhaszova, H. Bradley Nuss, Su Wang, Dmitry B. Zorov, Edward G. Lakatta, Steven J. Sollott

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

35 Scopus citations

Abstract

Although the heart rapidly adapts cardiac output to match the body's circulatory demands, the regulatory mechanisms ensuring that sufficient ATP is available to perform the required cardiac work are not completely understood. Two mechanisms have been suggested to serve as key regulators: (1) ADP and Pi concentrations - ATP utilizationhydrolysis in the cytosol increases ADP and Pi fluxes to mitochondria and hence the amount of available substrates for ATP production increases; and (2) Ca²⁺ concentration - ATP utilizationhydrolysis is coupled to changes in free cytosolic calcium and mitochondrial calcium, the latter controlling Ca²⁺-dependent activation of mitochondrial enzymes taking part in ATP production. Here we discuss the evolving perspectives of each of the putative regulatory mechanisms and the precise molecular targets (dehydrogenase enzymes, ATP synthase) based on existing experimental and theoretical evidence. The data synthesis can generate novel hypotheses and experimental designs to solve the ongoing enigma of energy supply-demand matching in the heart.

Original language	English (US)
Title of host publication	Analysis of Cardiac Development
Subtitle of host publication	From Embryo to Old Age
Publisher	Blackwell Publishing Inc.
Pages	133-142
Number of pages	10
ISBN (Print)	9781573317474
DOIs	https://doi.org/10.1111/j.1749-6632.2009.05093.x
State	Published - Feb 2010
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1188
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

ATP synthase
Bioenergetics
Mitochondria
Respiration

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1111/j.1749-6632.2009.05093.x

Cite this

Yaniv, Y., Juhaszova, M., Nuss, H. B., Wang, S., Zorov, D. B., Lakatta, E. G., & Sollott, S. J. (2010). Matching ATP supply and demand in mammalian heart: In vivo, in vitro, and in silico perspectives. In Analysis of Cardiac Development: From Embryo to Old Age (pp. 133-142). (Annals of the New York Academy of Sciences; Vol. 1188). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.05093.x

Matching ATP supply and demand in mammalian heart: In vivo, in vitro, and in silico perspectives. / Yaniv, Yael; Juhaszova, Magdalena; Nuss, H. Bradley et al.
Analysis of Cardiac Development: From Embryo to Old Age. Blackwell Publishing Inc., 2010. p. 133-142 (Annals of the New York Academy of Sciences; Vol. 1188).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yaniv, Y, Juhaszova, M, Nuss, HB, Wang, S, Zorov, DB, Lakatta, EG & Sollott, SJ 2010, Matching ATP supply and demand in mammalian heart: In vivo, in vitro, and in silico perspectives. in Analysis of Cardiac Development: From Embryo to Old Age. Annals of the New York Academy of Sciences, vol. 1188, Blackwell Publishing Inc., pp. 133-142. https://doi.org/10.1111/j.1749-6632.2009.05093.x

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Matching ATP supply and demand in mammalian heart: In vivo, in vitro, and in silico perspectives

Abstract

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Keywords

ASJC Scopus subject areas

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