Mass spectrometry for genotyping: An emerging tool for molecular medicine

Peta E. Jackson; Peter F. Scholl; John D. Groopman

doi:10.1016/s1357-4310(00)01698-1

Mass spectrometry for genotyping: An emerging tool for molecular medicine

Peta E. Jackson
, Peter F. Scholl
, John D. Groopman

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Recent technological innovations have made proteins and nucleic acids accessible to mass spectrometric analysis. As a result of their inherently high specificity, accuracy and throughput, there is considerable interest in developing mass spectrometric methods for genotype analysis in clinical diagnostic and research applications. This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry.

Original language	English (US)
Pages (from-to)	271-276
Number of pages	6
Journal	Molecular Medicine
Volume	6
Issue number	7
DOIs	https://doi.org/10.1016/s1357-4310(00)01698-1
State	Published - Jul 2000

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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10.1016/s1357-4310(00)01698-1

Cite this

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title = "Mass spectrometry for genotyping: An emerging tool for molecular medicine",

abstract = "Recent technological innovations have made proteins and nucleic acids accessible to mass spectrometric analysis. As a result of their inherently high specificity, accuracy and throughput, there is considerable interest in developing mass spectrometric methods for genotype analysis in clinical diagnostic and research applications. This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry.",

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year = "2000",

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N2 - Recent technological innovations have made proteins and nucleic acids accessible to mass spectrometric analysis. As a result of their inherently high specificity, accuracy and throughput, there is considerable interest in developing mass spectrometric methods for genotype analysis in clinical diagnostic and research applications. This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry.

AB - Recent technological innovations have made proteins and nucleic acids accessible to mass spectrometric analysis. As a result of their inherently high specificity, accuracy and throughput, there is considerable interest in developing mass spectrometric methods for genotype analysis in clinical diagnostic and research applications. This review outlines some of the most promising genotyping methods developed using electrospray and matrix-assisted laser-desorption-ionization mass spectrometry.

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U2 - 10.1016/s1357-4310(00)01698-1

DO - 10.1016/s1357-4310(00)01698-1

M3 - Review article

C2 - 10859563

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VL - 6

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JO - Molecular Medicine

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Mass spectrometry for genotyping: An emerging tool for molecular medicine

Abstract

ASJC Scopus subject areas

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